Description
An introduction to the immune system, antigens, antibodies and lymphocytes. The course will cover the cellular and molecular basis of lymphocyte development and mechanisms of lymphocyte activation in immune responses. MIMM314 provides basic knowledge of immunology, the molecular mechanisms of innate and adaptive immunity, and the immune system in health and disease.
3 credits — Winter Term
Pre-requisites: BIOL 200 Molecular Biology , BIOL 201 Cell Biology & Metabolism , or BIOC 212 Molec Mechanisms of Cell Funct
Lectures: T/Th 08:35 - 09:55
mimm-314_2012_syllabus-post.pdf
Details
Course Coordinator
Dr. Ciro Piccirillo
Montreal General Hospital
1650 Cedar Avenue
Room L11.132-144
Montreal, QC H3G 1A4
Tel: (514) 934-1934 ext: 45135
Fax: (514) 934-8332
ciro [dot] piccirillo [at] mcgill [dot] ca (Email)
Lecturers
Dr. R. Alizadehfar
Dr. S. Fournier
Dr. C. Krawczyk
Dr. J. Madrenas
Dr. C. McCusker (514) 412-4470
Dr. C. Piccirillo
Dr. C. Tsoukas
Evaluation
- Mid-Term Examinations (2 x 20%) - 40%
- Final Examination - 60%
Course Text
Janeway's Immunobiology, 7th Edition. ISBN 0815341237; Garland Publishing Inc.Immunobiology: The Immune System in Health and Disease, 5th Edition. Janeway, Travers, Walport, Shlomchik; Garland Publishing Inc.
In Depth
With knowledge gained primarily in mouse and human, the following are studied in sufficient detail to provide a basis for reading original biomedical research papers (as required in MIMM414, for example): Anatomical and functional description of lymphoid tissues and hematopoietic lineages; Several of the important molecules and mechanisms of innate immunity; The differentiation and selection of T and B lymphocytes and the generation of receptor and immunoglobulin diversity; Antigen processing and presentation; Lymphocyte activation and effector functions, including some intracellular signalling pathways; Intercellular signalling in the control of cell trafficking, activation and activity; Allergy; Self and non-self recognition as it relates to transplantation, surveillance against aberrant cells such as cancer cells, and autoimmunity; Inherited and acquired immune deficiencies. A survey of the cellular and molecular elements that constitute the immune system. This will provide the basis for an analysis of cellular interactions and molecular mechanisms which support protective immunity and will be considered in the context of dysregulated immune responses associated with autoimmunity and states of immunodeficiency.
Topics
- Innate Immunity, Complement and Receptors
- Hematopoietic and Lymphoid Tissues
- Immunoglobulin Structure
- Antigen-Receptor Interactions
- Generation of Antibody and T cell Receptor Diversity
- MHC Class I and MHC Class II Genes and Proteins
- Antigen Processing and Presentation
- Signal Transduction by Antigen Receptors and others
- B and I lymphocyte cell Development and the generation of diversity
- T Cell Development
- Lymphocyte Maturation and Survival
- T Cell Activation
- T Cell Mediated Immunity
- B Cell Activation
- Immunoglobulins and Immunoglobulin Receptors
- Cytokines and Chemokines
- Allergy
- Autoimmunity
- Immunological tolerance, Transplantation and Rejection
- Immunological Tolerance
- Tumour Immunology
- Inherited Immune Deficiencies
- Acquired Immune Deficiencies
immuno314 [at] gmail [dot] ca (Email for all queries related to this course.)