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Jörg Hermann Fritz

Assistant Professor

McGill Life Sciences Complex
Complex Traits Group
Bellini Pavilion
3649 Promenade Sir William Osler,
Room: 371 (Office) & 356 (Lab)
Montreal, QC H3G 0B1
Canada
jorg [dot] fritz [at] mcgill [dot] ca (Email)

Office: (514) 398-1707
Lab: (514) 398-6417
Fax: (514) 398-2603

Complex Traits Group - Web page

Research Orientations

The laboratory of Jörg Hermann Fritz focuses on understanding how innate host resistance regulates inflammatory and antigen-specific adaptive immune responses. In particular, he investigates how innate immune recognition of microbes and of infection-associated physiological changes activates pattern recognition molecules (PRM) such as Toll-like receptors (TLR) and Nod-like receptors (NLR) for the activation of mucosal and systemic immunity against commensal and pathogenic microorganisms. Focusing on the NLR members Nod1 and Nod2, the laboratory further studies the molecular and immunological consequences of innate immune recognition by non-hematopoietic stromal cells for the regulation of mucosal homeostasis as well as for the initiation of inflammatory and adaptive immune responses.

Bookchapters

L. A. M. Carneiro, J. H. Fritz, T. A. Kufer, L. H. Travassos, S. Benko, and D. J. Philipott. (2009) Chapter 8.8.3, NLRs: Nucleotide-Binding Domain and Leucine-Rich-Repeat-Containing Proteins.

In A. Böck, R. Curtiss III, J. B. Kaper, P. D. Karp, F. C. Neidhardt, T. Nyström, J. M. Slauch, and C. L. Squires and D. Ussery (ed.), EcoSal -- Escherichia coliand Salmonella: cellular and molecular biology. Chapter 8.8.3.

http://www.ecosal.org. ASM Press, Washington, DC. doi: 10.1128/ecosal.8.8.3

Selected Recent Publications

2011

Fritz J.H. and Gommerman J.L. (2010) "Cytokine Networks and Lymphoid Tissue Environments." Journal of Interferon and Cytokine Resarch

2010

Sellge G., Magalhaes J.G., Konradt C., Fritz J.H., Salgado-Pabon W., Eberl G., Bandeira A., Di Santo J.P., Sansonetti P.J., Phalipon A. (2010) "Th17 cells are the dominant T Cell subtype primed by Shigella flexneri mediating protective immunity". Journal of Immunology 184(4):2076-85

2009

Le Bourhis L., Magalhaes J.G., Selvanantham T., Travassos L.H., Geddes K., Fritz J.H., Viala J., Tedin K., Girardin S.E., Dana J. Philpott (2009) "Role of Nod1 in mucosal dendritic cells during Spi-1 independent Salmonella infection". Infect Immun. 2009 Oct;77(10):4480-6

2008

Fritz J.H.*, Magalhaes J.G.*, F, Le Bourhis L., Sellge G., Travassos L. H., Gommerman J.L., Girardin S.E., Philpott D.J. (2008) "Nod2-dependent Th2 polarization of antigen-specific immunity". Journal of Immunology 181, 7925-7935
(* both authors contributed equally to this work)

Proell M., Riedl S.J., Fritz J.H., Rojas A.M., Schwarzenbacher R. (2008) "The Nod-like Receptor (NLR) Family: a Tale of Similarities and Differences". PLOS One Apr30;3(4):e2119

Fritz J.H., Le Bourhis L., Magalhaes J.G., Philpott D.J. (2008) "Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat". Trends in Immunology 29(1):41-49

2007

Werts C., Le Bourhis L., Liu J., Magalhaes J.G., Carneiro L.A., Fritz J.H., Stockinger S., Balloy V., Chigniard M., Decker T., Philpott D.J., Ma X. and Girardin S.E. (2007) "Nod1 and Nod2 induce CCL5/RANTES through the NF-B pathway". Eur J Immunol 37(9), 2499-2508

Fritz J.H., Le Bourhis L., Sellge G., Fsihi H., Kufer T.A., Collins C., Viala J., Magalhaes J.G., Ferrero R.L., Girardin S.E., Philpott D.J. (2007) "Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity". Immunity, 26(4), 445-459

Glomski I.J., Fritz J.H., Keppler S.J., Viviane Balloy V., Chignard M., Mock M., Goossens P.L. (2007) "Murine Splenocytes Produce Inflammatory Cytokines in a MyD88-dependent Response to Bacillus anthracis spores". Cellular Microbiology 9(2), 502-513

2006

Fritz J.H., Ferrero R.L., Philpott D.J. & Girardin S.E. (2006) "Nod-like proteins in immunity, inflammation and disease". Nat Immunology.2006 Dec;7(12):1250-1257

Fritz J.H., Girardin S.E., Philpott D.J. (2006) "Innate Immune Defense Through RNA Interference". Sci. STKE 2006, pe27

Schellack C., Prinz K., Egyed A., Fritz J.H., Wittmann B., Ginzler M, Swatosch G., Zauner W., Kast C., Akira S., von Gabain A., Buschle M., Schmidt W., Lingnau K. (2006) "IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses". Vaccine 24, 5461-5472

2005

Fritz J.H., Girardin S.E. (2005) "How Toll-like receptors and Nod-like receptors contribute to innate immunity in mammals". J. Endotoxin Research, 11 (6), 390-394

Kufer T.A., Fritz J.H., Philpott D. J. (2005) "NACHT-LRR proteins (NLRs) in bacterial infection and immunity". Trends Microbiol 13(8), 381-388

Gamelas Magalhaes J., Philpott D.J., Nahori MA., Jéhanno M., Fritz J.H., Le Bourhis L., Viala J., Hugot JP., Giovannini M., Bertin J., Lepoivre M., Mengin-Lecreulx D., Sansonetti PJ., Girardin S.E. (2005) "Murine Nod1 but not its human ortholog mediates innate immune detection of tracheal cytotoxin". EMBO reports 6, 1201-1207

Fritz J.H., Girardin S.E., Fitting C., Werts C., Mengin-Lecreulx D., Caroff M., Cavaillon J.M., Philpott D.J., Adib-Conquy M. (2005) "Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists". Eur J Immunol 35(8), 2459-2570

2004

Fritz, J.H., Brunner, S., Birnstiel, M.L., Buschle, M., Gabain, A., Mattner, F., Zauner, W. (2004) "The artificial antimicrobial peptide KLKLLLLLKLK induces adaptive immunity to co-injected antigens". Vaccine,22,3274-3284

2002

Mattner, F., Fleitmann, J.K., Lingnau, K., Schmidt, W., Egyed, A., Fritz, J.H., Zauner, W., Wittmann, B., Gorny, I., Berger, M., Kirlappos, H., Otava, A., Birnstiel, M.L., Buschle, M. (2002) "Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens". Cancer Res.Mar 1;62(5):1477-80

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