Development of antimicrobials, antibiotic resistance, crystallography
Bellini Life Sciences Building
3649 Promenade Sir-William-Osler
Montreal, QC H3G 0B1
Tel: (514) 398-8795
Fax: (514) 398-2036
albert [dot] berghuis [at] mcgill [dot] ca (Email)
Canada Research Chair in Structural Biology
Med e-News: The bacteria is in the details
Interview in the Reporter: Turning Drug Design on its Head
Structure-based Drug Design is a scientific approach towards drug discovery. The approach involves examining the detailed structure of a protein—often an enzyme—whose (mal-)functioning is responsible for a disease. This information can be used to design compounds that specifically interact with that protein, thereby correcting its functioning. Such compounds are, in principal, drugs against the disease
The Berghuis Lab uses X-ray crystallography to obtain detailed structural information of proteins and is subsequently using this information for Structure-based Drug Design efforts. We are targeting bacterial and fungal infections, and antibiotic resistance.
Find out more by visiting the Berghuis Laboratory web site.