Associate Member; Medicine
Induction of autoantibodies and pathology in systemic lupus erythematosus
Division of Rheumatology
Montreal General Hospital
1650 Cedar Avenue
Montreal, QC H3G 1A4
Tel: (514) 934-1934 x.42149
Fax: (514) 934-8239
My research focuses on understanding the induction and pathogenesis of autoantibodies in autoimmune disease, particularly, anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE). APS occurs primarily in individuals with SLE, and is defined by the presence of anti-phospholipid antibodies (aPL) and a clinical event (e.g., thrombosis). However, it is unclear why only some patients with aPL develop clinical events. We propose that aPL alone are insufficient to cause thrombotic events, and that a concomitant trigger of innate immunity (e.g., toll-like receptor activation) is required. We use both in vitro and in vivo models to study the role of the innate immune system in the induction and pathogenesis of APS and SLE. Collaborative studies using clinical specimens are also an important component of the research in my laboratory, and complement the studies using murine models.
Selected recent publications
Levine, J.S., Subang, R., Nasr, S.H., Fournier, S., Lajoie, G., Wither, J., and Rauch, J. Immunization with the apoptotic cell‑binding protein, β2‑glycoprotein I, in the presence of lipopolysaccharide recapitulates both autoantibody emergence and nephritis of human SLE. J. Immunol. 177: 6504–6516, 2006 (PMID: 17056583).
Dieudé, M., Striegl, H., Tyznik, A.J., Wang, J., Behar, S.M., Piccirillo, C.A., Levine, J.S., Zajonc, D.M., and Rauch, J. Cardiolipin binds to CD1d and stimulates CD1d-restricted gd T cells in the normal murine repertoire. J. Immunol. 186: 4771-4781, 2011 (PMID: 21389252).
Dieudé, M., Correa, J.A., Neville, C., Pineau, C., Levine, J.S., Subang, R., Landolt-Marticorena, C., Su, J., Kassis, J., Solymoss, S., Fortin, P.R., and Rauch, J. Autoantibodies to heat shock protein 60 are associated with arterial vascular events in patients with anti-phospholipid antibodies. Arthritis Rheum. 63: 2416-2424, 2011 (PMID: 21506099).
Laplante, P., Amireault, P., Subang, R., Dieudé, M., Levine, J.S., and Rauch, J. Interaction of β2-glycoprotein I with lipopolysaccharide leads to toll-like receptor 4 (TLR4)-dependent activation of macrophages. J. Biol. Chem. 286: 42494–42503, 2011 (PMID: 21965665).