Associate Professor of Medicine
Nitric Oxide Biology, Reactive Oxygen Species, NADPH oxidase, Angiogenesis, Apoptosis Vascular Biology
Critical Care Division
Royal Victoria Hospital
687 Pine Avenue West
Montreal, QC H3A 1A1
Tel: (514) 934-1934 x.34645
sabah [dot] hussain [at] muhc [dot] mcgill [dot] ca (Email)
- Regulation of cellular redox state and biology of nitric oxide with particular reference to inflammation
- Angiognesis (regulation of endothelial tube formation by angiopoietins and VEGF)
- Cellular Apoptosis (regulation of various apoptotic pathways by angiogenesis factors)
- Ventilatory muscle function and regulation of their blood flow
Selected Recent Publications
Barreiro E., Comtois A, Mohammed S, Lands L, and SN Hussain Role of heme oxygenases in sepsis-induced diaphragmatic contractile dysfunctions and oxidative stress. Am. J. Physiol. (Lung Cell. Mol. Biol): 283: L476-L484, 2002
Harfouche R, Hassessian HM, Guo Y, Faivre V, Srikant CB, Yancopoulos GD, and SN Hussain Mechanisms which mediate the antiapoptotic effects of angiopoietin-1 on endothelial cells. Microvasc Res. 2 002 Jul;64(1):135-47.
Barreiro E, Comtois AS, Gea J, Laubach VE, and SN Hussain Protein tyrosine nitration in the ventilatory muscles: role of nitric oxide synthases. Am J Respir Cell Mol Biol. 2002 Apr;26(4):438-46.
Ye F, Florian M, Magder SA, and SN Hussain Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Steroids. 2002 Mar;67(3-4):305-10.
Javesghani D, Magder SA, Barreiro E, Quinn MT, and SN Hussain. Molecular characterization of a superoxide-generating NAD(P)H oxidase in the ventilatory muscles. Am J Respir Crit Care Med. 2002 Feb 1;165(3):412-8.