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Amit Bar-Or

Professor
Neurology and Neurosurgery

Amit Bar-Or

Memory B cells and T cells; Co-stimulation; Autoimmune Diseases; Multiple Sclerosis (MS)

Department of Neurology and Neurosurgery
Montreal Neurological Institute
3801 University, Room 111
Montreal, QC H3A 2B4
Tel: (514) 398-5950
Fax: (514) 398-7371
amit [dot] bar-or [at] mcgill [dot] ca (Email)

Research Orientations

My research is directed at understanding the basic properties of B cells and T cells and the ways in which they may participate in neurological diseases. I am particularly interested in studying memory B cell and memory T cell responses, their interactions, and their relevance to the disease multiple sclerosis.

Another focus of my research relates to the investigation of novel therapeutics in multiple sclerosis and the development and application of biological assays to monitor the disease process and evaluate response to treatment.

Selected Recent Publications

Bar-Or A. "The Immunology of Multiple Sclerosis. In: Multiple Sclerosis and Other Demyelinating Disorders of the CNS; Guest Editor, Lucchinetti, CF." Semin Neurol 28(1):5–21, 2008.

Rieger A and Bar-Or A. "B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators." Nat Rev Immunol. Jun; 8(6):486-487, 2008.

Bar-Or A, Calabresi P, Arnold D.L., Markowitz C, Shafer S, Kasper L, Waubant E, Gazda S, Fox R, Panzara M, Sarkar N, Agarwal S, Smith C. "Safety, pharmacodynamics, and activity of Rituximab in patients with relapsing-remitting multiple sclerosis: a phase I, multicentre, open-label clinical trial." Accepted, Ann Neurol, 2008.

Hauser S, Waubant E, Arnold D, Vollmer T, Antel J, Fox R, Bar-Or A, Sarkar N, Langer-Gould A, Panzara M, Smith C. "B-cell depletion with Rituximab in relapsing-remitting multiple sclerosis." NEJM, 14; 358(7):676-88, 2008.

Banwell B, Bar-Or A*, Cheung R3, Kennedy J1, Becker DJ, Dosch HM*, on behalf of the Wadsworth Pediatric Multiple Sclerosis Study. "Abnormal T cell reactivities to target-organ and environmental antigens in childhood multiple sclerosis and diabetes implicate both shared and distinct autoimmune disease mechanisms." Ann Neurol. 63(1):98-111;2008.

Pool M, Thiemann J, Bar-Or A, Fournier A. "NeuriteTracer: A novel ImageJ plugin for automated quantification of neurite outgrowth." J Neurosci Meth, 168(1):134-9. 2008.

Bar-Or A*, Vollmer T*, Antel J, Arnold D, Bodner C, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi FY, Utz PJ, Valone F, Weiner L, Steinman L and Garren H. "Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase I/II trial." Arch Neurol, 64(10):1407-15, 2007.

Banwell* B, Krupp L, Tellier R, Kennedy J, Tenembaum S, Ness J, Belman A, Boiko A, Bykova O, Waubant E, Mah J, Stoian C, Kremenchutzky M, Ruggieri M, Rensel M, Hahn J, Weinstock-Guttman B, Yeh A, Farrell K, Freedman M, Iivanainen M, Stephens D and Bar-Or A*. "Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study." Lancet Neurol, 6(9):773-81, 2007.

Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, Kim HJ, Bar-Or A*. "Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis." J Immunol, 15;178(10):6092-9, 2007.

O’Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Tenembaum S, Wong SL, Rostasy K, Dale R, Freedman M, Steinman L, Hafler DA, Wucherpfennig KW. "Self-Antigen Tetramers Discriminate between Myelin Autoantibodies to Native or Denatured Protein." Nat Med, 13(2):211-7, 2007.

Kilpatrick LM, Harris RL, Owen KA, Bass R, Ghorayeb C, Bar-Or A*, Ellis V*. "Initiation of plasminogen activation on the surface of monocytes expressing the type-II transmembrane serine protease matriptase." Blood, 15;108(8):2616-23,2006.

Niino M, Bodner C,, Simard ML, Alatab S, Gano D, Kim HJ, Trigueiro M, Racicot D, Guérette C, Antel JP, Fournier A, Grand’Maison F, Bar-Or A*. "Natalizumab effects on Immune Responses in multiple sclerosis." Ann Neurol, 59(5):748-54; 2006.

Magnus T, Schreiner B, Korn T, Jack C, Antel JP, Ifergan I, Chen L, Bar-Or A*, Wiendl H*. "Microglial expression of the B7-family member B7homolog 1 confers strong immune inhibition: implications for immune response and autoimmunity in the CNS." J Neurosci, 25(10):2537-2546, 2005.

Kim HJ, Ifergan I, Antel JP, Seguin R, Duddy M, Lapierre Y, Jalili F, Bar-Or A. "Type-2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis." J Immunol, 2004.

Duddy ME, Alter A, Bar-Or A. "Distinct profiles of human B cell effector cytokines: A role in immune regulation?" J Immunol, 2004.

Bar-Or A, Nuttall RK, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR, Yong VW. "Analyses of all matrix metalloproteinase members in leuckocytes emphasize monocytes as major inflammatory mediators in Multiple Sclerosis." Brain 126:1-12, 2003. Co-first authors.

Antel JP and Bar-Or A. "Do myelin antibodies predict the diagnosis of multiple sclerosis?" NEJM, 349(2):107-109, 2003.

Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-Or A. "Determinants of human B cell migration across brain endothelial cells." J Immunol, 170(9):4497-4505, 2003.