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Danielle Malo

 

DVM; PhD
Associate Professor

Mailing address
McGill Life Sciences Complex, Bellini Building
3649 Promenade Sir-William-Osler, room 369
Montreal, QC, H3G 0B1

Contact Information
Office Phone: (514) 398-3907
Lab Phone: (514) 398-2816
Fax: (514) 398-2603

Email
danielle [dot] malo [at] mcgill [dot] ca

Publications:
Link to Pubmed

 

 

Research interests

Research interests in my laboratory have been focused on the identification and functional characterization of genes that control the host response to infection with Gram-negative bacteria and to lipopolysaccharide (LPS), an abundant glycolipid of the outer membrane of Gram-negative bacteria able to provoke a generalized proinflammatory response in the infected host. We are using a strategy of comparative genomics which consists of mapping and identifying genes for resistance to infectious disease in model organisms such as the mouse and then testing their orthologues as candidate genes for susceptibility to related infection in humans and in economically important farm animals. Using mouse models and an approach of positional cloning, we have identified two host resistance genes (Bcg and Lps) involved in innate response to infection with Gram-negative bacteria. We have developed novel mouse models of septic shock and chronic infection to identify novel genes involved in host response to Gram-negative infection using quantitative trait loci (QTL) analysis.

Departmental affiliation

Department of Medicine; Department of Human Genetics

Accepting students from

Medicine; Human Genetics; Microbiology and Immunology; Biochemistry; Biology