Host resistance is a field of study that seeks to explain the diverse nature of resistance to disease. This is a real challenge, because so many diseases like asthma, infectious diseases and cancer, are chronic conditions where multiple genes interact with each other and with environmental factors. Only by dissecting a disease into its discrete stages can the entire host response be understood. Establishment of the genetic control and biological functions at each stage of disease also makes opportunities for disease intervention.
Dr Emil Skamene realized that the key to discovering resistance genes is in the skilled, imaginative design and testing of experimental stages of specific diseases. To best accomplish this goal, he founded the Centre for the Study of Host Resistance in 1988. The Centre today has 24 researchers who have various expertise in immunoparasitology, genetic modeling of disease, genome mapping and functional genomics, biostatistics and vaccine development. The strong collaborative energy in the Centre has helped to unveil many prospects for the control of clinically significant diseases.