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NIH - Drug discovery and mechanisms of microbial resistance study section

Project Information
Description: 

The Drug Discovery and Mechanisms of Antimicrobial Resistance [DDR] Study Section reviews applications that are concerned with the identification of novel antimicrobial, antifungal, and antiparasitic agents for the prevention and treatment of infectious diseases and the study of the evolution, mechanisms, and transmission of resistance.

Project Date: 
2011-01-01 - 2022-09-29
Type of Project: 
Research
Research Area: 
Health Research
Sub-Research Area: 
Drug research

Location

United States

McGill University Project Leader Information

Project Leader: 

Albert M. Berghuis

Primary Position

Faculty: 
Faculty of Medicine
Department: 
Biochemistry
Position/Appointment: 
Professor
Other Position/Appointment: 
Canada Research Chair in Structural Biology
Research Interests: 
Various research programs are being pursued in the Berghuis lab. However, all programs share a common theme in that they use structural biological approaches to examine interactions between enzymes and small molecules (e.g. substrates, cofactors, inhibitors). The principal technique used for these studies is X-ray crystallography, complemented with small-angle X-ray scattering, electron microscopy, nuclear magnetic resonance spectroscopy, enzymology and computational chemistry tools. Furthermore, for many of these programs, efforts are ongoing to exploit the three-dimensional structural information for drug development using structure-based drug design approaches.
Role: 
Principal Investigator