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NIH - Drug discovery and mechanisms of microbial resistance study section

Project Information

The Drug Discovery and Mechanisms of Antimicrobial Resistance [DDR] Study Section reviews applications that are concerned with the identification of novel antimicrobial, antifungal, and antiparasitic agents for the prevention and treatment of infectious diseases and the study of the evolution, mechanisms, and transmission of resistance.

Project Date: 
01/01/2011 to 09/29/2022
Type of Project: 
Research Area: 
Health Research
Sub-Research Area: 
Drug research
United States
McGill University Project Leader Information
Project Leader: 

Albert M. Berghuis

Profile Picture: 
Primary Position
Faculty of Medicine
Other Position/Appointment: 
Canada Research Chair in Structural Biology
Research Interests: 
Various research programs are being pursued in the Berghuis lab. However, all programs share a common theme in that they use structural biological approaches to examine interactions between enzymes and small molecules (e.g. substrates, cofactors, inhibitors). The principal technique used for these studies is X-ray crystallography, complemented with small-angle X-ray scattering, electron microscopy, nuclear magnetic resonance spectroscopy, enzymology and computational chemistry tools. Furthermore, for many of these programs, efforts are ongoing to exploit the three-dimensional structural information for drug development using structure-based drug design approaches.
Principal Investigator