Mechanism of action of novel HCV NS5A inhibitors
McGill University Project Leader Information
Faculty:Faculty of Medicine
Department:Microbiology & Immunology
Research Interests:Research in his group is focused on structure-function relationships of viral enzymes, with emphasis placed on mechanisms involved in drug action and drug resistance. The reverse transcriptase (RT) of HIV-1, the RNA-dependent RNA polymerase and helicase of the hepatitis C virus (HCV), and herpes virus DNA polymerases are major themes. The lab is actively involved in the development of novel classes of compounds that block the DNA polymerase activity of wild-type HIV-1 RT and its resistant variants.