Coming from a 20-year career in the pharmaceutical industry, I have a strong background in drug discovery and in all aspects of the pharmacology of antiparasitic drugs. This work includs the molecular identification of drug targets through functional genomic analysis of helminth physiology and the engineering of recombinant systems for high-throughput screening for new antiparasitic leads.
My lab does research on drug targets in parasites and on the chemotherapy of antiparasitic drugs. In addition, my interests include basic work on the proteins secreted by parasites and hosts that determine the success of infection. Proteomic analysis of the ‘secretome’ of filarial parasites, and the manner in which drugs such as ivermectin affect the secretome, is a focus of my research. This program encompasses both protozoal parasites of human and veterinary importance and includes international collaborators. I am currently looking for students to join my laboratory.