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Bases neuro-anatomiques de la douleur psychique dans la dépression et les conduites suicidaires

Project Information

Investigating with functional Magnetic Resonance Imaging (MRI) the neural basis of the vulnerability to suicidal behavior in patients with a personal history of depression. A task of social exclusion is being used to measure the sensitivity to social pain. Three groups are compared: patients with a history of suicidal behavior and depression, patient controls with a history of depression but no history of suicidal act, and healthy controls.

Project Date: 
2011-01-01 - 2022-10-06
Type of Project: 
Research Area: 
Health Research
Sub-Research Area: 
Mental health



McGill University Project Leader Information

Project Leader: 

Fabrice Jollant

Primary Position

Faculty of Medicine
Other Institute: 
Douglas Mental Health University Institute
Assistant Professor
Other Position/Appointment: 
Attending Psychiatrist
Research Interests: 
Suicidal behavior, depressive disorders, cognition, neuroimaging

- M.D. (1991-1997): Paris, school of medicine, France - Specialty in Psychiatry (1997-2004): Montpellier, school of medicine, France - M.Sc. (2002): University Montpellier I, France - Visiting research associate (2004-2005): Institute of psychiatry, London, UK - Ph.D. (2007): University Montpellier I, France - Chef de clinique - assistant des hôpitaux then Praticien Hospitalier Universitaire (2005-2010): Montpellier, school of medicine, France - Assistant professor (since 2010): McGill University, Montréal - Attending psychiatrist and researcher (since 2010): Douglas Mental Health University Institute, Montréal

Selected Publications: 

Jollant F., Bellivier F., Leboyer M., Astruc B., Torres S., Verdier R., Castelnau D., Malafosse A., Courtet P. Impaired decision-making in suicide attempters. Am J Psychiatry 2005; 162(2): 304-10.

Jollant F., Lawrence N., Giampietro V., Brammer M.J., Fullana M.A., Drapier D., Courtet Ph., Phillips M.L. Orbitofrontal cortex response to angry faces in men with histories of suicide attempters. Am J Psychiatry 2008; 165(6): 740-8.

Jollant F., Lawrence NS., Olié E., O’Daly O., Malafosse A., Courtet Ph., Phillips ML. Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior. Neuroimage. 2010 Jul 1; 51(3): 1275-81.

Jollant F., Lawrence NS., Olié E., Guillaume S, Courtet P. The suicidal mind and brain: a review of neuropsychological and neuroimaging studies. World J Biol Psychiatr. 2011; 12(5): 319-39.

Jollant F, Malafosse A, Docto R, Macdonald C. A pocket of very high suicide rates in a non-violent, egalitarian and cooperative population of South-East Asia. Psychol Med. 2014 Jan 17:1-7.

Principal Investigator

Non-McGill Partners


Philippe Courtet

University of Montpellier & INSERM U1061