Schistosomiasis is one of the major burdens on African health and health systems. Changes in the Global climate, considered the biggest health threat of C21, could exacerbate the problem and hit the poorest countries hardest. Furthermore, environmental change, whether a natural phenomenon or through human intervention, impacts the ecological balance and context within which humans and their livestock live, and how their parasites and pathogens evolve and transmit. Our multidisciplinary proposal is of key strategic importance as its results will help elucidate the connectivity between the changing environment and parasite dynamics, and in particular how this influences the interdependence between humans, livestock, their shared parasites, and thereby ultimately the impact on human and animal health and disease control. We will determine an accurate burden of disease, particularly in terms of novel and emerging human-animal hybrid schistosome infections, and thereby define and predict populations at current and future risk of infection and disease. This will be achieved through the use of new, ethical, affordable and accessible molecular, phenotypic and geospatial modelling tools and technologies. Furthermore, the prime positions of the PI’s and co-applicants supports local and endemic-country research, helps enable effective policy change and thereby ensure implementation of improved disease control. The overall objective is, with a focus on Niger, Mali and Senegal, to determine the spatial and temporal distribution and dynamics of human and animal schistosomiasis transmission and its association with changing environmental settings including alterations in climatic conditions, urbanization, agriculture and land use.