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Personal Information
Firstname: 
Albert M.
Lastname: 
Berghuis
Profile Picture: 
Primary Position
Faculty: 
Faculty of Medicine
Department: 
Biochemistry
Position/Appointment: 
Professor
Other Position/Appointment: 
Canada Research Chair in Structural Biology
Research Interests: 
Various research programs are being pursued in the Berghuis lab. However, all programs share a common theme in that they use structural biological approaches to examine interactions between enzymes and small molecules (e.g. substrates, cofactors, inhibitors). The principal technique used for these studies is X-ray crystallography, complemented with small-angle X-ray scattering, electron microscopy, nuclear magnetic resonance spectroscopy, enzymology and computational chemistry tools. Furthermore, for many of these programs, efforts are ongoing to exploit the three-dimensional structural information for drug development using structure-based drug design approaches.