Quick Links

Dr. Lawrence Goodridge - Associate Professor, Ian and Jayne Munro Chair in Food Safety

Associate Professor & Ian and Jayne Munro chair in food-safety

Department of Food Science and Agricultural Chemistry
Macdonald Campus, McGill University
21,111 Lakeshore
Ste. Anne de Bellevue, Quebec
H9X 3V9

Email: lawrence [dot] goodridge [at] mcgill [dot] ca
Tel.: 514-398-7921
Fax: 514-398-7977


Postdoctoral Fellow, University of Georgia, Center for Food Safety. 2002. Project: Molecular subtype analysis of multidrug resistant isolates of Salmonella enterica

Ph.D. Food Science, University of Guelph, 2002.  Dissertation Title: A Reporter Bacteriophage – Beta-galactosidase Assay for Detection of Generic Escherichia coli from Beef Carcasses.

M.Sc. Food Science, University of Guelph, 1997. Thesis title: A Fluorescent Bacteriophage Assay for Detection of Escherichia coli O157:H7 in Ground Beef and Raw Milk.

B.Sc. Microbiology, University of Guelph, 1995

Research Interests

Food Microbiology and Safety

Effective use of Bacteriophages to control and detect foodborne pathogens.

Bacteriophages (phages) are considered to be among the most numerous and diverse entities on earth, with an estimated 10e30 – 10e31 phage particles within the biosphere.  Phages are widely distributed in locations populated by bacterial hosts, such as soil, the mammalian gastrointestinal tract, food and sea water. Since phages are often found in environments where their bacterial hosts are also found, it stands to reason that phages are constantly interacting with bacteria in these environments. The susceptibility of a bacterium to phage infection is initially dependent on whether the phage can attach to receptors on the bacterial cell surface. A successful phage attachment facilitates entry of the phage nucleic acid into the cell, which may then lead to replication and release of new phage progeny.    While there are several mechanisms employed by bacteria to resist phage infection, a primary method is to stop phage attachment through alteration (mutation) of cell surface exposed phage receptors.  Since many of the surface exposed proteins and carbohydrates that act as phage receptors also play a primary role in bacterial fitness, the ability of a given bacterial isolate to survive in a specific environment will likely be affected by phage induced mutations in the LPS and OMPs.  These statements raise questions surrounding the effect of phage induced mutations on Omps, with respect to changes in bacterial fitness within a given environment. As with the Omps, mutations in LPS can affect bacterial fitness, as the LPS serves as an important component of the permeability barrier of the cell and is involved in cell wall stability. The T4 like phages constitute a diverse group of lytic, double stranded DNA tailed phages belonging to Family Myoviridae, which infect evolutionary distinct bacteria.  The T4 like phages are excellent candidates for the study of comparative genomics and phage evolution, and they are also attractive tools with which to study the interactions between phage and bacteria. 

We have developed a model system by which we can study the development of phage resistance in bacteria, elucidate the underlying mechanisms of that resistance, and determine the consequences of phage resistance on the fitness of bacterial foodborne pathogens.  These studies will not only provide information regarding the mechanisms employed by bacteria to resist phage attack and subsequent bacterial fitness consequences, but is also important because phages are an emerging class of antimicrobials being used in food, and a number of commercial phage antimicrobial products are already being utilized.  It will be important to understand the consequences to phage resistance in foodborne pathogens as a result of the use of phages as antimicrobials.


Teaching responsibilities

Introduction to Food Science. - 8304 - FDSC 200 – 001

Current Food Safety Issues. - 15591 - FDSC 624 - 001

Selected Recent Publications


Pérez-Méndez, A., Chandler, J. C., Bisha, B., Coleman, S. M., Zhanqiang,S., Gang, Y.,  Goodridge, L. D.  2013. Evaluation of a Simple and Cost Effective Filter Paper-Based Shipping and Storage Medium for Environmental Sampling of F-RNA Coliphages. Journal of Virological Methods. Available online 15 August 2013.


McEgan, R., Rodrigues, C.A., Sbodio, A., Suslow, T.V., Goodridge, L. D., and Danyluk, M.D. 2013. Detection of Salmonella spp. from large volumes of water by modified Moore swabs and tangential flow filtration. Letters in Applied Microbiology 56:88-94.


Goodridge, L.D. 2013.Bacteriophages for managing Shigella in various clinical and non-clinical settings.  Bacteriophage 3(1): 1-10.


McEgan, R., Mootian, G., Goodridge, L.D., Schaffner, D.W., and Danyluk, M.D.2013. Predicting Salmonella populations from biological, chemical, and physical indicators in Florida surface waters. Applied and Environmental Microbiology.  79:4094-4105.


Pendleton, S. J., Story, R., O’Bryan, C. A., Crandall, P. G., Ricke, S.C., Goodridge L. 2012. A membrane filtration method for determining minimum inhibitory concentrations of essential oils. Agriculture, Food and Analytical Bacteriology 2:88-93.


Bisha, B., Simonson, J., Janes, M., Bauman, K., Goodridge, L. D. 2012. A review of the current status of cultural and rapid detection of Vibrio parahaemolyticus. International Journal of Food Science and Technology. 47:885-899.


Pittman, C., Geornaras, I., Woerner, D., Nightingale, K., Sofos, J., Goodridge, L., Belk, K. 2012. Evaluation of Lactic Acid as an Initial and Secondary Subprimal Intervention for Escherichia coli O157:H7, Non-O157 Shiga Toxin-Producing E. coli, and a Non-Pathogenic E. coli Surrogate for E. coli O157:H7. Journal of Food Protection. 75:1701-1708.


Pendleton, S. J., Crandall, P. G., Ricke, S.C., Goodridge L., O’Bryan, C. A. 2012. Inhibition of Beef Isolates of E. coli O157:H7 by Orange Oil at Various Temperatures. Journal of Food Science. 77:M308–M311.


Jokerst, J. C., Adkins, J. A., Bisha, B., Mentele, M. M., Goodridge, L. D., Henry, C. S. 2012. Development of a Paper-Based Analytical Device for Colorimetric Detection of Select Foodborne Pathogens. Analytical Chemistry. 84:2900−2907.


Harris, L. J., Bihn, E. A., Bender, J., Blessington, T.,Danyluk, M. D., Delaquis, P., Goodridge, L., Ibekwe, A. M., Ilic, S., Kniel, K., LeJeune, J. T., Schaffner, D. W., Stoeckel, D., Suslow, T. V. 2012. Framework for Developing Research Protocols: Evaluating Microbial Hazards and Controls during Production that Pertain to the Quality of Agricultural Water contacting Produce that may be consumed Raw.  Journal of Food Protection. 75:2251-2273.