Andrew Vickers, PhD. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center
Wednesday September 18th, 2013
3:00 to 4:00
We will resume our regular schedule Tuesday's from 3:30 to 4:30 on September 24th, 2013
Epidemiology Seminar Series: Dr. S. Suissa - Safety trials of long-acting beta-agonists in asthma: methodological issues
Dr. Samy Suissa, James McGill Professor of Epidemiology, Biostatistics and Medicine, McGill University Director, Centre for Clinical Epidemiology, Lady Davis Research Institute - Jewish General Hospital
Topic: Safety trials of long-acting beta-agonists in asthma: methodological issues
1) To review observational and randomized studies of beta-agonist safety in asthma
2) To introduce and define non-inferiority randomized trials
Biostatistics Seminar - Dr. Bradley P. Carlin - A Bayesian Missing Data Framework for Multiple Outcome Mixed Treatment Comparisons.
Biostatistics Seminar - Dr Paul Albert - Joint models for multivariate longitudinal measurements and a binary event: An application to predicting poor pregnancy outcomes from longitudinal ultrasound measurements
Biostatistics Seminar - Dr Peter Thall - Utility Based Dose-Finding with Ordinal Toxicity and Efficacy
Biostatistics Seminar - Dr Jinko Graham - A test drive of haplotype-informed ancestries for fine mapping complex genetic traits.
A basic tenet of statistical genetics is that shared ancestry underlies population associations between complex traits and genetic markers such as haplotypes. The coalescent is a popular mathematical model of the ancestral tree of copies of a genetic locus sampled from the population. While these ancestral trees cannot be observed directly, the observed haplotype data enable sampling from their posterior distribution. For each sampled tree, statistical tests of shared ancestry among extreme phenotypes may be applied to summarize the trait association.
Recursive Polya tree mixture model: a new Bayesian nonparametric model.
Biostatistics Seminar: Dr. Robert Platt - Methodological Challenges in Drug Safety Research: the Canadian Network for Observational Drug Effect Studies.
Jose R. Zubizarreta - Designing an observational study to be less sensitive to unmeasured biases: effect of the 2010 Chilean earthquake on posttraumatic stress.
In 2010, a magnitude 8.8 earthquake hit Chile, devastating parts of the country. Having just completed its national socioeconomic survey (CASEN), Chile interviewed a subsample of respondents, creating unusual longitudinal data about the same individuals before and after a major disaster. The follow-up evaluated posttraumatic stress symptoms (PTSS) using Davidson’s Trauma Scale. We use these data with two goals in mind. Most studies of PTSS following disasters rely on recall to characterize the state of affairs prior to the disaster. In contrast, we use the CASE