svetlana [dot] komarova [at] mcgill [dot] ca (Email)
Dr. Komarova’s research program is aimed at understanding the regulation of osteoclasts, the cells responsible for bone destruction in diseases such as osteoporosis, rheumatoid arthritis, periodontitis and bone metastases. Osteoclasts are highly active cells, present in bone only in small numbers. Moreover, osteoclasts are terminally differentiated, and therefore do not proliferate in culture. To understand the mechanisms that determine stimulus-specific gene expression in osteoclasts, Dr. Komarova’s laboratory employs high-speed imaging of live cells, quantitative gene expression analysis, as well as mathematical modeling. These studies will provide new insights into the control of bone resorption in health and disease, which may lead to the development of new therapies for treatment of inflammatory, metabolic and metastatic bone disorders. Dr. Komarova completed a M.Sc. degree in physics at the Moscow State University, Russia, and obtained a Ph.D. degree in biophysics in 1996 from the Institute of Theoretical and Experimental Biophysics, Pushchino, Russia. Before joining the Faculty of Dentistry, Dr. Komarova completed postdoctoral training at NASA Ames Research Center, and in the CIHR Group in Skeletal Development and Remodeling, The University of Western Ontario.
Selected publications over the last 5 years
Abdelaziz DM, Stone LS, Komarova SV. (2014) Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin. Breast Cancer Res Treat 143(2):227-37.
Rafiei S, Komarova SV. (2013) Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells. BMC Cancer. 26;13:605.
Maria SM, Prukner C, Sheikh Z, Mueller F, Barralet JE, Komarova SV. (2013) Reproducible quantification of osteoclastic activity: Characterization of a biomimetic calcium phosphate assay. J Biomed Mater Res Part B E-pub Nov 21.
K Tiedemann, I Boraschi-Diaz, I Rajakumar, J Kaur, P Roughley, DP Reinhardt, SV Komarova (2013) Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J. Cell Sci 126(Pt 18):4187-94.
JE. Fong, D Le Nihouannen, K Tiedemann, G Sadvakassova, JE. Barralet, SV Komarova (2013) Moderate excess of pyruvate augments osteoclastogenesis. Biology Open 22;2(4):387-95.
M Durand, SV Komarova, A Bhargava, K Li, C Fiorino, N Nabavi, Morris F. Manolson, RE. Harrison, S. J Dixon, SM. Sims, M J. Mizianty, O. Maria, L Kurgan, G Boire, M de Fatima Lucena-Fernandes, AJ. de Brum-Fernandes, (2013) Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis (IODA) study. Arthritis and Rheumatism;65(1):148-58.
Ryser M D., Qu Y, Komarova SV. (2012) OPG in bone metastases: mathematical solution to the puzzle. PLoS Computational Biology 8(10): e1002703 (NSERC)
GM Lopez A, DJ Oliver, PH Grutter, SV Komarova (2012) Deconvolution of calcium fluorescent indicator signal from AFM cantilever reflection. Microscopy and Microanalysis 30:1-8.
Kaiser J, Lemaire T, Naïli S, Sansalone V, Komarova SV (2012) Calcium fluxes within cortical bone fluid may affect osteocytes mechanosensitivity. Journal of Theoretical Biology 303, 75–86
Hussein O, Tiedemann K, Murshed M, Komarova SV (2012) Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases. Cancer Letters. 314(2):176-84
JE Fong, SV Komarova (2011) Breast Cancer Metastases to Bone: Role of the Microenvironment, Breast Cancer - Focusing Tumor Microenvironment, Stem cells and Metastasis, Mehmet Gunduz and Esra Gunduz (Ed.), ISBN: 978-953-307-766-6, InTech.
Hussein O., Komarova SV (2011) Breast Cancer at Bone Metastatic Sites: Recent Discoveries and Treatment Targets. Journal of Cell Communication and Signaling 5(2):85-99. (Rev)
Durand M, Boire G, Komarova SV, Dixon SJ, Sims SM, Harrison RE, Nabavi N, Maria O, Manolson MF, Mizianty M, Kurgan L, de Brum-Fernandes AJ.(2011) The increased in vitro osteoclastogenesis in patients with rheumatoid arthritis is due to increased percentage of precursors and decreased apoptosis - the In Vitro Osteoclast Differentiation in Arthritis (IODA) study. Bone. 48(3):588-96.
Hussein O, Tiedemann K, Komarova SV. (2011) Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis. Bone, 48(2):202-11.
Fong JE, Le Nihouannen D, Komarova SV. (2010) Breast cancer-derived factors create metastases-supportive bone microenvironment: key role of gamma-secretase. Journal of Biological Chemistry 285(41): 31427-34.
Pivonka P, Komarova SV. (2010) Mathematical modeling in bone biology: from intracellular signaling to tissue mechanics. Bone. 47(2): 181-9 (Rev)
Ryser M.D., S.V. Komarova, N. Nigam. (2010) The cellular dynamics of bone remodelling: a mathematical model. SIAM Journal of Applied Mathematics. 70, 6, 1899-1921.
Le Nihouannen D., Barralet JE, Fong JE, Komarova SV (2010) Ascorbic acid accelerates osteoclast formation and death. Bone. 46(5):1336-43.
Tiedemann K, Hussein O, Sadvacassova G, Guo Y, Siegel PM, Komarova SV (2009) Breast cancer derived factors stimulate osteoclastogenesis through synergy between the Ca2+/PKC and TGFbeta/MAPK signaling pathways. Journal of Biological Chemistry, 284(48): 33662-70
Kemeny-Suss N., Kasnesi A., Rivas D., Afilalo J., Komarova S.V., Chalifour L., Duque G. (2009) Alendronate Affects Calcium Dynamics in Cardiomyocytes. Vasc Pharmacol; 51(5-6): 350-8.
Ryser MD, Nigam N, Komarova SV. (2009) Mathematical Modeling of Spatio-Temporal Dynamics of a Single Bone Multicellular Unit. J Bone Miner Res. 24(5): 860-70