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Mervyn Gornitsky

mgornits [at] den [dot] jgh [dot] mcgill [dot] ca (Email)

Dr. Mervyn Gornitsky Director of Research
Department of Dentistry
SMBD – Jewish General Hospital
3755 Côte Ste-Catherine
Montréal, Québec H3T 1E2

Phone: 514-340-7911

Research associated with Facial Pain and Myofascial Pain Dysfuntion Syndrome. As well, we are in the process of reporting on various systemic diseases associated with Periodontitis and their inter-relationship. The venue in which I function is within the dental department of the Sir Mortimer B. Davis-Jewish General Hospital. Due to the large number of in-house consultations and out patients, we have a large group of cohorts from which to recruit for our various clinical studies. In the past we have reported on epidemiologic studies associated with Facial Pain and Bruxism, Periodontal Diseases in the HIV positive and AIDS patients, Xerostomia in-patients having had radiotherapy for head and neck cancer and at present we are in the midst of a study associating periodontal disease and Preeclampsia. We are constantly searching for innovative clinical studies.

We have developed a saliva data bank with 1200 samples at the Jewish General Hospital to allow us to study the effects of oxidative stress on saliva. We are focusing on lipids, proteins, DNA as well as total oxidative capacity as markers for various diseases e.g. Periodontitis, Scleroderma, Diabetes type 1 & 2. We have completed the studies on Periodontal Disease and Scleroderma, continuing on Diabetes type 1 & 2 and starting solid Cancers probably breast.

PUBLICATIONS

Gornitsky M: Hospital Dental Residency Program - Why? Journal of the Canadian Dental Association, 4: 182-184, 1979.

Gornitsky M: Calcifying Epithelial Odontogenic Tumor - A Case Report. Journal of International Oral Surgery: 10:Suppl: 1: 37- 41, 1981.

Gornitsky M: The Undergraduate Elective in Hospital Dentistry - An Innovative Educational Experience. Journal of the Canadian Dental Association, 3: 173-174, 1983.

Gornitsky M, Shevell M: Osteoradionecrosis of the Mandible - A Case Report. Journal of the Canadian Dental Association, 1: 95- 98, 1984.

Pekovic DD, Chausseau J-P, Lapointe N, Michaud J, Garzon S, Strykowski H, Tsoukas C, Gilmore N, Goldman H, Gornitsky M, Popovic M, Dupuy J-M: Detection of HTLV-III/LAV antigens in peripheral blood lymphocytes from patients with AIDS. Arch Virol 91:11-19, 1986.

Pekovic DD, Garzon S, Strykowski H, Ajdukovic D, Gornitsky M, Dupuy J-M: Immunogold labeling of HTLV-III/LAV in H9 cells studied by transmission electron microscopy. J Virol Meth 13:265-269, 1986.

Pekovic DD, Ajdukovic D, Tsoukas C, Lapointe N, Michaud J, Gilmor N, Gornitsky M: HIV in salivary lymphocytes from dental patients with AIDS. Am J Med 82:188-189, 1987.

Pekovic DD, Gornitsky M, Ajdukovic D, Dupuy J-M, Chausseau J-P, Michaud J, Lapointe N, Gilmore N, Tsoukas C, Zwadlo G, Popovic M: Pathogenicity of HIV in lymphatic organs of patients with AIDS. J Path 152:31-35, 1987.

Pekovic DD, Adamkiewicz VW, Shapiro A, Gornitsky M: Identification of bacteria in association with immune components in human carious dentin. J Oral Pathol 16:223-233, 1987.

Gornitsky M, Pekovic DD: Involvement of human immunodeficiency virus (HIV) in gingiva of patients with AIDS. Recent Advances in Mucosal Immunology, Part A. Mestecky J, McGhee J, Bienenstock J, Ogra P. (Eds), Plenum Publishing Corp., 553-562, 1987.

Clark D.C., Tyler M.T., Fisher R.M., Gornitsky M., Williams J. " Clinical evaluation of patient acceptance for a mucin-containing artificial saliva with and without chlorhexidine". Journal of Oral Medicine, 2: 121-124, 1987.

Pekovic DD, Gornitsky M, Garzon S, Strykowski H, Adamkiewicz VW, Ajdukovic D: Mechanisms of HIV-associated immunosuppression. Immunobiology of Cancer and Aids: Etiology, Diagnosis and Management. Allan R. Liss, Inc., New York, 1988.

Pekovic DD, Gornitsky M, Garzon S, Strykowski H, Adamkiewicz VW, Zwadlo G, Ajdukovic D: Mechanisms of HIV-associated immunosuppression. Cancer Detect Prev. 12:195-203, 1988

Pekovic DD, Adamkiewicz VW, Gornitsky M: Immunoglobulins in human dental caries: Archs Oral Biol, 2: 135-141, 1988.

Sboo R, Al-Joburi W, Gornitsky M, Chan ECS: "Synthesis and secretion of phospholipase C by oral spirochetes", Journal of Clinical Microbiology, March 1989.

Tremblay M, Gornitsky M, Wainberg M.A: Active replication of human immunodeficiency virus type 1 by peripheral blood mononuclear cells following coincubation with herpes viruses. Journal of Medical Virology 29:109-114, 1989.

St-Germain P, Altshuller B, Gornitsky M: La transplantation dentaire autogene - une alternative de traitment pour combler un espace edente, Journal Dentaire du Quebec,Vol. XXVII: 321-324, July 1990.

Tremblay M, Numazaki K, Li X, Gornitsky M, Hiscott J, Wainberg M: Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralising antibodies. Journal of Immunology, Vol.145, 9: 2896-2901, Nov. 1990.

Gryllis C, Wainberg M, Gornitsky M, Brenner B: Diminution of inducible lymphokine-activated killer cell activity in individuals with AIDS-related disorders. AIDS 12: 1205-1212, 1990.

Brenner B, Gryllis C, Gornitsky M, Cupples W, Wainberg M: Differential effects of chemotherapy-induced and HIV-l-induced immunocompromise on NK and LAK activities using breast cancer and HIV-l seropositive patient populations. Journal of Anticancer Research, 3: 969-974, February 1991.

Gornitsky M, Clark DC, Siboo R, Amsel R, Iugovaz I, Wooley C, Iuliani N and Chan ECS: "Clinical documentation and occurrence of putative periodontopathic bacteria in HIV-Associated periodontal disease." Journal of Periodontology, 9, p. 576-585, September 1991.

Miller B.A., Gornitsky M: "Benign mucous membrane pemphigoid: A Case Report", Journal of the Canadian Dental Association, 10: 799-800, October 1991.

Gryllis C, Wainberg M, Bentwich Z, Gornitsky M, Brenner B.G: "Increased LAK activity against HIV-infected cell lines in HIV-1+ individuals." Clin. Exp. Immunol. 89:356-361, 1992.

Iuliani N, Des Rivieres D, Provencal M, Gornitsky M: Etude de l'efficacite du programme de rappel des porteurs du VIH soumis a un traitement d'hygiene buccale. L'Explorateur, Vol. 3, no. 1, 1993.

Brenner B.G, Gornitsky M, Wainberg M.A: "Adaptive changes in induced natural immune response during the course of HIV-l infection". Can. Journal of Infect. Dis., Vol. 4, suppl. B, p. 11B, 1993.

Brenner B.G, Gryllis C, Gornitsky M, Wainberg M.A: "Changes in natural immunity during the course of HIV-l infection". Clin Exp Immunol, 93:142-148, 1993.

Reinish E.I, Raviv M, Srolovitz H, Gornitsky M: "Tongue, primary amyloidosis, and multiple myeloma". Oral Surg Oral Med Oral Pathol; 77:121-5, 1994.

Brenner B.G, Gornitsky M, Wainberg M.A: "Interleukin-2-inducible natural immune (lymphokine-activated killer cell) responses as a functional correlation of progression to AIDS". Clin. Diagn. Lab. Immunol. 538-544, Sept. 1994.

Prosterman B, Prosterman L, Fisher R, Gornitsky M: "The use of implants for orthodontic correction of an open bite". American Journal of Orthodontics and Dentofacial Orthopedics, 107: 245-250, 1995.

Harel-Raviv M, Eckler M, Lalani K, Raviv E, Gornitsky M: "Nifedipine-induced gingival hyperplasia - A comprehensive review and analysis". Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 79: 715-22, 1995

Harel-Raviv M, Raviv E, Srolovitz H, Gornitsky M: "Pemphigus vulgaris - The potential for error: A case report". Special Care in Dentistry, 15: p.61-64, March/April 1995.

Harel-Raviv M, Bernier S, Raviv E, Gornitsky M: "Oral epidermolysis bullosa in adults". Special Care in Dentistry, 15: 144-148, July/August 1995.

Touyz L, Harel-Raviv M, Prosterman B, Gornitsky M: "Candidal infection of the tongue together with candidal infection of the palate in patients with the human immunodeficiency virus". Quintessence International, 27: 89-92, 1996.

Phuc Vinh Le, Gornitsky M: "Oral stent as treatment adjunct for oral submucous fibrosis". Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 81:148-50, 1996.

Raviv E, Harel-Raviv M, Shatz P, Gornitsky M: "Implant-supported overdenture rehabilitation and progressive systemic sclerosis". The International Journal of Prosthodontics, 9: 440-444, 1996.

Harel-Raviv M, Eckler M, Raviv E, Gornitsky M: "Fourth Molars: A Clinical Study". Dental Update, 23: 9, November, 1996.

Brawer JR, McCarthy GF, Gornitsky M, Frankel D, Mehindate K, Schipper HM : "Mercuric Chloride Induces a Stress Response in Cultured Astrocytes Characterized by Mitochondrial Uptake of Iron". NeuroToxicology, 19(6) 767-776, 1998.

Gornitsky M, Paradis DH, Landaverde G, Malo AM, Velly AM "A Clinical and Microbiological Evaluation of Denture Cleansers for Geriatric Patients in Long Term Care Institutions". Journal of the Canadian Dental Association , 68(1) 39-45, 2002.

Velly AM, Gornitsky M, Philippe PA "A Case-Control Study of Temporomandibular Disorders. Symptomatic Disc Displacement". Journal of Oral Rehabilitation, 29(5) 408-416, 2002.

Velly AM, Philippe PA, Gornitsky M "Heterogenity of Temporomandibular Disorders. - Cluster and Case Control Analysis". Journal of Oral Rehabilitation, 29(10) 969-979, 2002.

Velly AM, Gornitsky M, Philippe PA "Contributing Factors to Chronic Myofascial Pain A Case-Control Study". Pain 104, 491-499, 2003.

Gornitsky M, Shenouda G, Sultanem K, Katz H, Hier M, Black M, Velly AM "Double-blind randomized, placebo-controlled study of pilocarpine to salvage salivary gland function during radiotherapy of patients with head and neck cancer". Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 98(1):45-52, 2004.

Rosen H, Gornitsky M "Cementable Implant-Supported Prosthesis, Serial Extraction, and Serial Implant Installation: Case Report". Implant Dentistry Vol.13, No.4, 322-325, 2004

Gornitsky M, Hammouda W, Rosen H "Rehabilitation of a hemophiliac with implants - a medical perspective and case report". Journal of Oral and Maxillofacial Surgery Vol. 63, No.5, 592-597, May 2005.

Haixiang Su, Gornitsky M, Guoyan Geng, Ana M. Velly, Howard Chertkow, Hyman M. Schipper: "Diurnal variations in salivary protein carbonyl levels in normal and cognitively impaired human subjects". AGE Vol. 30, No. 1, 1-9 Mar. 2008.

Haixiang Su, Gornitsky M, Ana M. Velly, Hanling Yu, Michael Benarroch, Hyman M. Schipper: "Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease". Free Radical Biology & Medicine, Vol. 46, No.7, 914-21 April 2009.

Su H, Baron M, Benarroch M, Velly AM, Gravel S, Schipper HM, Gornitsky M. J Rheumatol: "Altered salivary redox homeostasis in patients with systemic sclerosis". 2010 Sep;37(9):1858-63. Epub 2010 Jul 1. PMID: 20595279 [PubMed - indexed for MEDLINE]

Baron M, Bernier P, Côté LF, Delegge MH, Falovitch G, Friedman G, Gornitsky M, Hoffer J, Hudson M, Khanna D, Paterson WG, Schafer D, Toskes PP, Wykes L: "Screening and therapy for malnutrition and related gastro-intestinal disorders in systemic sclerosis: recommendations of a North American expert panel". Clin Exp Rheumatol 2010 Mar-Apr;28(2 Suppl 58):S42-6. Epub 2010 Jun 10. PMID: 20576213 [PubMed - indexed for MEDLINE]

Su H, Velly AM, Salah MH, Benarroch M, Trifiro M, Schipper HM, Gornitsky M: "Altered redox homeostasis in human diabetes saliva". J Oral Pathol Med. 2011 Nov 14. doi: 10.1111/j.1600-0714.2011.01092.x. [Epub ahead of print] PMID: 22077396 [PubMed - as supplied by publisher]

Taghzouti N, Xiong X, Gornitsky M, Chandad F, Voyer R, Gagnon G, Leduc L, Xu H, Tulandi T, Wei B, Sénécal J, Velly AM, Salah MH, Fraser WD. J Periodontol: "Periodontal Disease is Not Associated With Preeclampsia in Canadian Pregnant Women". 2011 Dec 22. [Epub ahead of print] PMID: 22191787 [PubMed - as supplied by publisher]