marta [dot] cerruti [at] mcgill [dot] ca (Email)
M. H. Wong Building, Room 2M020
3610 University St.
Montreal, QC H3A 2B2
Fax: 514 398 4492
Marta Cerruti is a chemist who specializes in the characterization and optimization of phenomena occurring at the interface between synthetic materials and biomolecules. She received her PhD in 2004 at the University of Torino, working on the application of techniques typical of physical chemistry to the study of bioactive glass surfaces, and how they changed upon immersion in simulated body fluids. Part of her PhD research was conducted at the University of Florida, in collaboration with Novamin Technologies, the company that at the time produced Bioglass® (BG). After her Ph.D. she worked as a post-doctoral fellow at North Carolina State University for 2 years, and then at UC Berkely for another 2 years. During these 2 post-docs she studied DNA sensors, explosive detection, graphene functionalization, RNA-mediated nanoparticle synthesis, and antimicrobial surfaces.
In September 2009 she joined the Department of Mining and Materials Engineering at McGill University as Assistant Professor. Her main interests are understanding and controlling surface phenomena, especially at the interface between synthetic materials and biological molecules. Current research focuses on three main thrusts:
(i) Biodegradable composite polymer/BG scaffolds: the scaffolds are prepared with different techniques that allow for variable control of the porosity; we strive to understand how BG and the polymeric matrix interact at their interface, control the scaffold degradation rate, and functionalize its surface so that it can enhance bone repair once implanted
(ii) Influence of biomolecules on hydroxyapatite (HA) crystallization: HA is the inorganic component of bones, and its nucleation and growth in the body is controlled by non-collagenous proteins. We strive to understand the functionalities in these proteins that induce or inhibit HA crystallization, and use smaller sequences (oligopeptides or even amino acids) to nucleate and grow HA in-vitro with controlled morphology at desired locations on model surfaces.
(iii) Oral delivery of calcitonin: this project is performed in collaboration with professor Jake Barralet, from Dentistry. We want to functionalize the surface of calcitonin carriers to allow absorption through the intestinal membrane
Cerruti M., Doersk G., Hernandez G., Carraro C., Maboudian R., "Galvanic deposition of Pt clusters on Si: effect of HF concentration and application as catalyst for silicon nanowire growth". Langmuir 26 (2010), 432-437 .
Greve A., Keller S., Vig A.L., Kristensen A., Larsson D., Yvind K., Hvam J., Cerruti M., Majumdar A., Boisen A., "Thermalplast Microcantilevers Fabricated by Nanoimprint Lithography". J. Micromech. Microeng. 20 (2010), 01500.
Franzen S., Rhodes C., Cerruti M., Gerber W., Efremenko A., Losego M., Maria J.-P., Aspnes D., "Plasmon Tuning by Materials Chemistry". Optics Lett. 34 (2010), 2867-2869.
Losego M. D., Efremenko E., Rhodes C., Cerruti M., Franzen S., Maria J. P., "Conductive oxide thin films: Model systems for understanding and controlling surface plasmon resonance", J. Appl. Phys. 106 (2009), 024903.
Cerruti M., Jaworski J., Raorane D., Zueger C., Varadarajan J., Carraro C., Lee S.-W., Maboudian R., Majumdar A., "Polymer-oligopeptide composite coating for selective detection of explosives", Anal. Chem. 81 (2009), 4192–4199.
Rhodes C., Cerruti M., Efremenko A., Losego M., Aspnes D., Maria J.-P., Franzen S., "Dependence of plasmon polaritons on the thickness of indium tin oxide thin films", J. Appl. Phys. 103 (2008) 93108 .
Leonard D., Cerruti M., Duscher G., Franzen S., "Interfacial and Solvent Effects Govern the Formation of Pd2(DBA)3 microstructures", Langmuir 24 (2008), 7803-7809.
Cerruti M., Fissolo S., Carraro C., Ricciardi C., Majumdar A., Maboudian R., "Poly(Ethylene Glycol) Monolayer Formation and Stability on Gold and Silicon Nitride Substrates", Langmuir 24 (2008), 10646–10653.
Cerruti M., Rhodes C., Losego M., Efremenko A., Maria J.-P., Fishcer D., Feldheim D., Franzen S., Genzer J., "Influence of Indium-Tin Oxide surface structure on the ordering and coverage of organosilane, carboxylic acid and thiol monolayers", J. Phys. D: Appl. Phys. 40 (2007), 4212-4221.
Franzen S., Cerruti M., Leonard D., Duscher G., "The Role of Selection Pressure in RNA-Mediated Evolutionary Materials Synthesis", J. Am. Chem. Soc. 129 (2007), 15340-15346.
Cerruti M., Sauthier M., Leonard D., Liu D., Duscher G., Feldheim D., Franzen S., "Gold and Silica-Coated Gold nanoparticles as Thermographic Labels for DNA Detection", Anal. Chem. 78 (2006), 3282-3288.
Cerruti M., Greenspan D., Powers K., "Effect of pH and ionic strength on the reactivity of Bioglass 45S5", Biomaterials 26 (2005), 1665-1674.
Cerruti M., Perardi A., Cerrato G., Morterra C., "Formation of a nan-structured layer on Bioglass particles of different size immersed in TRIS-buffered solution: N2 adsorption and HR-TEM/EDS analysis", Langmuir 21 (2005), 9327-9333.
Cerruti M., Morterra C., Ugliengo P., "Surface features of P-doped silica explored with CD3CN adsorption: Can Si atoms act as Lewis centers?"
Cerruti M., Bianchi C., Bonino F., Damin A., Perardi A., Morterra C., "Surface modifications of Bioglass immersed in TRIS-buffered solution: A multi-technical spectroscopic study", J. Phys. Chem. B. 109:30 (2005), 146-14505.
Cerruti M., Morterra C., "Carbonate formation on bioactive glasses", Langmuir 20 (2004), 6382-6388.
Cerruti M., Bolis V., Magnacca G., Morterra C., "Surface chemical functionalities in bioactive particle size samples of Bioglass in TRIS-buffered solution", Biomaterials 24 (2004), 4903-4911.
Cerruti M., Morterra C., Ugliengo P., "Surface features of P-doped silica: a comparison between IR spectroscopy and theoretical modeling", J. Mater. Chem. 14 (2004), 3364-3369.
Cerruti M., Magnacca G., Bolis V., Morterra C, "Characterization of sol-gel bioglasses with the use of simple model systems: a surface-chemistry approach", J. Mat. Chem. 13 (2003), 1279-1286.
Cerruti, M., Sahai N., Silicate "Biomaterials for Orthopaedic and Dental Implants" p. 283-313 in Medical Mineralogy and Geochemistry, Reviews in Mineralogy and Geochemistry 64, edited by Nita Sahai and Martin Schoonen, Mineralogical Society of America and Geochemical Society, 2006.