January 2010

CRN Publications

Ghasemlou N, Bouhy D, Yang J, López-Vales R, Haber M, Thuraisingam T, He G, Radzioch D, Ding A, David S. Beneficial effects of secretory leukocyte protease inhibitor after spinal cord injury. Brain. 2010 Jan;133(Pt 1):126-38.

Girolami EI, Bouhy D, Haber M, Johnson H, David S.Differential expression and potential role of SOCS1 and SOCS3 in Wallerian degeneration in injured peripheral nerve. Exp Neurol. (In Press).

López-Vales R, Redensek A, Skinner TAA, Rathore KI, Ghasemlou N, Wojewodka G, DeSanctis J, Radzioch D, David S. Fenretinide promotes functional recovery and tissue protection after spinal cord contusion injury in mice. Journal of Neuroscience (In Press).

December 2009

Congratulations to Dr. Brian Chen who has been appointed the Tier II Canada Research Chair (CRC) in Neural Circuit Formation. He also received funding from the Canadian Foundation for Innovation (CFI) for the construction of a "Facility for High-Resolution in vivo Imaging of Synapse Dynamics in Multiple Model Systems."

CRN Publications

Prager-Khoutorsky M, Bourque CW. Osmosensation in vasopressin neurons: changing actin density to optimize function. Trends Neurosci. 2009 Dec 4. E-Pub ahead of print

November 2009

CRN Publications

Ferguson K, Long H, Cameron S, Chang WT, Rao Y. The conserved Ig superfamily member Turtle mediates axonal tiling in Drosophila. J Neurosci. 2009 Nov 11;29(45):14151-9.

Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS. Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009 Nov 15;18(22):4390-404.

October 2009

CRN Publications

Long H, Ou Y, Rao Y, van Meyel DJ. Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila. Development. 2009 Oct;136(20):3475-84.

September 2009

CRN Publications

Berard JL, Wolak K, Fournier S, David S. Characterization of relapsing-remitting and chronic forms of experimental autoimmune encephalomyelitis in C57BL/6 mice. Glia. 2009 Sep 24;58(4):434-445.

Fry EJ, Chagnon MJ, López-Vales R, Tremblay ML, David S.Corticospinal tract regeneration after spinal cord injury in receptor protein tyrosine phosphatase sigma deficient mice. Glia. 2009 Sep 24;58(4):423-433.

July 2009

CRN Publications

Carmona MA, Murai KK, Wang L, Roberts AJ, Pasquale EB. Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12524-9.

Haber M, Vautrin S, Fry EJ, Murai KK. Subtype-specific oligodendrocyte dynamics in organotypic culture. Glia. 2009 Jul;57(9):1000-13.

June 2009

Congratulations to Dr. Don van Meyel who received a three year Hugh and Helen McPherson Memorial Award through the McGill Faculty of Medicine.

The CRN congratulates Jessica Sudbury in the lab of Dr. Charles Bourque who received a 3 year Canada Graduate Scholarship Doctoral Award from CIHR.

The CRN congratulates Dr. Masha Khoutorsky in the lab of Dr. Charles Bourque who received a 2 year Postdoctoral Fellowship from the Heart and Stroke Foundation of Canada.

May 2009

CRN Publications

Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain. 2009 May;132(Pt 5):1221-35.

April 2009

Congratulations to Dr. Don van Meyel who was awarded a multi-year NSERC Discovery Grant titled: "Discovery and analysis of genes that govern axon guidance in the developing nervous system"

Congratulations to Dr. Sam David and colleagues who were awarded a 6 year CIHR grant for an "Integrated Training Program in Basic and Clinical Aspects of Neuroinflammation."

February 2009

CRN Publications

Tremblay ME, Riad M, Chierzi S, Murai KK, Pasquale EB, Doucet G. Developmental course of EphA4 cellular and subcellular localization in the postnatal rat hippocampus. J Comp Neurol. 2009 Feb 20;512(6):798-813.

January 2009

Congratulations to Dr. Don van Meyel who received a 5 year grant from CIHR titled, "Glial cell differentiation, function and neuron-glial interactions in the CNS."

Congratulations to Dr. Sam David who received a 5 year grant from CIHR titled, "Molecular mechanisms underlying the onset and resolution of macrophage activation in the nervous system: implications for neural injury and repair."

We are pleased to announce the arrival of Dr. Brian Chen (Assistant Professor in the Departments of Neurology & Neurosurgery and Medicine) at the Centre for Research in Neuroscience. Dr. Chen obtained his Ph.D. at the Cold Spring Harbor Laboratory and performed postdoctoral work at Harvard. His research is focused on understanding mechanisms involved in brain wiring and plasticity using invertebrate and vertebrate model systems.

CRN Publications

Schmucker D, Chen B. Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes. Genes Dev. 2009 Jan 15;23(2):147-56.

Jeong SY, Rathore KI, Schulz K, Ponka P, Arosio P, David S. Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2009 Jan 21;29(3):610-9.

December 2008

CRN Publications

Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet. 2008 Dec 15;17(24):3965-74.

Salomon SN, Haber M, Murai KK, Dunn RJ. Localization of the Diaphanous-related formin Daam1 to neuronal dendrites. Neurosci Lett. 2008 Dec 5;447(1):62-7.

Novemeber 2008

CRN Publications

Martini R, Fischer S, López-Vales R, David S. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia. 2008 Nov 1;56(14):1566-77.

Rathore KI, Kerr BJ, Redensek A, López-Vales R, Jeong SY, Ponka P, David S. Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. J Neurosci. 2008 Nov 26;28(48):12736-47.

September 2008

Drs. Stellwagen and Murai receive a 2 year NIH grant to study the role of glial-derived TNF-alpha in regulating the structural and functional properties of synapses in response to drugs of abuse.

CRN Publications

Martini R, Fischer S, López-Vales R, David S. Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease. Glia. 2008 Sep 19;56(14):1566-1577.

Piton A, Michaud JL, Peng H, Aradhya S, Gauthier J, Mottron L, Champagne N, Lafrenière RG, Hamdan FF; S2D team, Joober R, Fombonne E, Marineau C, Cossette P, Dubé MP, Haghighi P, Drapeau P, Barker PA, Carbonetto S, Rouleau GA. Mutations in the calcium-related gene IL1RAPL1 are associated with autism. Hum Mol Genet. 2008 Sep 18. [Epub ahead of print]

Sharif-Naeini R, Ciura S, Stachniak TJ, Trudel E, Bourque CW. Neurophysiology of supraoptic neurons in C57/BL mice studied in three acute in vitro preparations. Prog Brain Res. 2008;170:229-42.

Zhou C, Rao Y, Rao Y. A subset of octopaminergic neurons are important for Drosophila aggression. Nat Neurosci. 2008 Sep;11(9):1059-67.

Zhang Z, Bourque CW. Amplification of transducer gain by angiotensin II-mediated enhancement of cortical actin density in osmosensory neurons. J Neurosci. 2008 Sep 17;28(38):9536-44.

August 2008

CRN Publications

López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Aug 21.

July 2008

Congratulations to Dr. Yann Bernardinelli (Murai Lab) who received a 1.5 year fellowship from the Fonds National Suisse De La Recherche Scientifique to study the role of glial cells in synaptic function.

CRN Publications

Bourque CW. Central mechanisms of osmosensation and systemic osmoregulation. Nat Rev Neurosci. 2008 Jul;9(7):519-31. Epub 2008 May 29.

Bouvier D, Corera AT, Tremblay ME, Riad M, Chagnon M, Murai KK, Pasquale EB, Fon EA, Doucet G. Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem. 2008 Jul;106(2):682-95.

Ou Y, Chwalla B, Landgraf M, van Meyel DJ. Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons. Neural Develop. 2008 Jul 10;3:16.

June 2008

CRN Publications

Kaneko M, Stellwagen D, Malenka RC, Stryker MP. Tumor necrosis factor-alpha mediates one component of competitive, experience-dependent plasticity in developing visual cortex. Neuron. 2008 Jun 12;58(5):673-80.

May 2008

CRN Publications

David S, Fry EJ, López-Vales R. Novel roles for Nogo receptor in inflammation and disease. Trends Neurosci. 2008 May;31(5):221-6.

April 2008

Congratulations to the members of the Bourque Laboratory who recently received independent fellowships. Jessica Sudbury received a Doctoral Award from the FRSQ (Fonds de la Recherche en Sante du Quebec) and Tevye Stachniak was awarded a Doctoral Award from the HSFC (Heart and Stroke Foundation of Canada).

CRN Publications

Bouvier D, Corera AT, Tremblay ME, Riad M, Chagnon M, Murai KK, Pasquale EB, Fon EA, Doucet G. Presynaptic and postsynaptic localization of EphA4 and EphB2 in adult mouse forebrain. J Neurochem. 2008 Apr 12; [Epub ahead of print]

David S, Fry EJ, López-Vales R. Novel roles for Nogo receptor in inflammation and disease. Trends Neurosci. 2008 Apr 3. [Epub ahead of print]

Murai KK, Pasquale EB. Neuroscience. Axons seek neighborly advice. Science. 2008 Apr 11;320(5873):185-6.

Peng H, Shah W, Holland P, Carbonetto S. Integrins and dystroglycan regulate astrocyte wound healing: The integrin beta1 subunit is necessary for process extension and orienting the microtubular network. Dev Neurobiol. 2008 Apr;68(5):559-74.

Sharif-Naeini R, Ciura S, Bourque CW. TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia. Neuron. 2008 Apr 24;58(2):179-85.

Sharif-Naeini R, Ciura S, Zhang Z, Bourque CW. Contribution of TRPV channels to osmosensory transduction, thirst, and vasopressin release. Kidney Int. 2008 Apr;73(7):811-5.

Tahvildari B, Alonso AA, Bourque CW. Ionic Basis of ON and OFF Persistent Activity in Layer III Lateral Entorhinal Cortical Principal Neurons. J Neurophysiol. 2008 Apr;99(4):2006-11.

March2008

CRN Publications

Kerr BJ, Girolami EI, Ghasemlou N, Jeong SY, David S. The protective effects of 15-deoxy-delta-(12,14)-prostaglandin J2 in spinal cord injury. Glia. 2008 Mar;56(4):436-48.

January 2008

We are pleased to announce the arrival of Dr. David Stellwagen as an Assistant Profesor in the Departments of Medicine and Neurology and the Centre for Research in Neuroscience. Dr. Stellwagen obtained a B.Sc. from Brown University and a PhD in Molecular and Cell Biology at Berkeley. He has 13 publications focused largely on understanding the mechanisms of synaptic remodeling in the brain.

December 2007

CRN Publications

Murai, KK, van Meyel, D.J. Neuron-glial communication at synapses: insights from vertebrates and invertebrates. The Neuroscientist. 2007 Dec;13(6):657-66.

Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci. 2007 Dec 19;27(51):14205-15.

November 2007

CRN Publications

Brown CH, Scott V, Ludwig M, Leng G, Bourque CW. Somatodendritic dynorphin release: orchestrating activity patterns of vasopressin neurons. Biochem Soc Trans. 2007 Nov;35(Pt 5):1236-42.

September 2007

CRN Publications

Bourgin C, Murai KK, Richter M, Pasquale EB. The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways. J Cell Biol. 2007 Sep 24;178(7):1295-307.

Khawaja FA, Alonso AA, Bourque CW. Ca(2+)-dependent K(+) currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells. Hippocampus. 2007;17(12):1143-8.

Stacey, S, Thomas, GB, Labbe, A, van Meyel, DJ. Longitudinal glia in the fly CNS: pushing the envelope on glial diversity and neuron-glial interactions Neuron-Glia Biology 2007 3(1):27-33.

August 2007

Drs. Louis Eric-Trudeau (U. of Montreal), Yong Rao (CRN), Edward Fon (MNI), David Park (U. Ottawa), Heidi McBride (U. Ottawa), and Michael Schlossmacher (U. Ottawa) receive a three year Team Grant Award from Neuroscience Canada Titled, "Mitochondrial dysfunction and neuronal demise: insights provided by Parkinson's disease genes." The award is for $1,500,000 over the 2007-2010 period.

CRN Publications

Kerr BJ, David S. Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. Exp Neurol. 2007 Aug;206(2):240-7.

Mindorff, EN, O'Keefe DD, Labbe, A, Yang, JP, Ou, Y, Yoshikawa, S, van Meyel, DJ. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein Dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting Genetics. 2007 176(4):2247-63.

July 2007

CRN Publications

Ellis LD, Krahe R, Bourque CW, Dunn RJ, Chacron MJ. Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current. J Neurophysiol. 2007 Jul 5 [e-pub ahead of print].

June 2007

Drs. Rob Dunn and Pierre Drapeau (University of Montreal) receive a five year grant from CIHR on "Developmental plasticity of the spinal cord synaptic drive."

CRN Publications

De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J. 2007 Jun 20;26(12):2823-31.

May 2007

CRN Publications

Bourque CW, Ciura S, Trudel E, Stachniak TJ, Sharif-Naeini R. Neurophysiological characterisation of osmosensitive neurons. Exp Physiol. 2007 May;92(3):499-505.

Kerr BJ, David S. Pain behaviors after spinal cord contusion injury in two commonly used mouse strains. Exp Neurol. 2007 May 21 [Epub ahead of print].

Zhou L, Martinez SJ, Haber M, Jones EV, Bouvier D, Doucet G, Corera AT, Fon EA, Zisch AH, Murai KK. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J Neurosci. 2007 May 9;27(19):5127-38.

April 2007

CRN Publications

Zhang Z, Kindrat AN, Sharif-Naeini R, Bourque CW. Actin filaments mediate mechanical gating during osmosensory transduction in rat supraoptic nucleus neurons. J Neurosci. 2007 Apr 11; 27(15): 4008-4013.

Tremblay ME, Riad M, Bouvier D, Murai KK, Pasquale EB, Descarries L, Doucet G. Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus. J Comp Neurol. 2007 Apr 10;501(5):691-702.

March 2007

Glezer I, Chernomoretz A, David S, Plante MM, Rivest S. Genes Involved in the Balance between Neuronal Survival and Death during Inflammation. PLoS ONE. 2007 Mar 21;2:e310.

Reza Sharif-Naeini from the lab of Dr. Charles Bourque was recently awarded CIHR's Brain Star Award (see http://www.cihr-irsc.gc.ca/e/33053.html). Reza was also recently awarded a prestigious Human Frontiers Long Term Fellowship Award for Postdoctoral studies to be pursued in France.

A recent paper by Graham Thomas and Dr. Don van Meyel was selected as a Research Highlight in the March 2007 Update of Nature Publishing Group's Functional Glycomics Gateway.

CRN Publications

Fry EJ, Ho C, David S. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron. 2007 Mar 1;53(5):649-62.

February 2007

Dr. Keith Murai receives a five year grant from CIHR on "Neuron-glial mechanisms that regulate synaptic morphology and function."

CRN Publications

Ghasemlou N, Jeong SY, Lacroix S, David S. T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS. Glia. 2007 Feb;55(3):294-302.

Thomas GB, van Meyel DJ. The glycosyltransferase Fringe promotes Delta-Notch signaling between neurons and glia, and is required for subtype-specific glial gene expression. Development. 2007 Feb;134(3):591-600.

January 2007

CRN investigators Drs. Sal Carbonetto, Yong Rao, Don van Meyel and Keith Murai, and investigators Drs. Patrick Cossette (University of Montreal, Neurology), Chieh Chang (McGill, Biology), David Juncker (McGill, Biomedical Engineering), Anne McKinney (McGill, Pharmacology), and Guy Rouleau (Univ. of Montreal, Neurology), receive a 5 year award for a team grant titled "Reorganization of Brain Microcircuits" from CIHR (Regenerative Medicine and Nanomedicine Initiative).

December 2006

CRN Publications

Sharif Naeini R, Ciura S, Bourque CW. TRPVs: ion channels that make you thirsty! Med Sci (Paris). 2006 Dec;22(12):1035-1037.

September 2006

CRN Publications

Jeong SY, David S. Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice. J Neurosci. 2006 Sep 20;26(38):9810-9.

August 2006

CRN Publications

Ciura S, Bourque CW. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J. Neurosci. 2006 August 30;26(35):9069-9075.

Haber M, Zhou L, Murai KK. Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses. J. Neurosci. 2006 August 30;26(35):8881-8891.

Research studies from the laboratories of Dr. Charles Bourque and Dr. Keith Murai are picked as featured articles for the August 30th issue of the Journal of Neuroscience.

July 2006

Dr. Don van Meyel receives a one year Development / Planning Grant (International Opportunities Program) from the Canadian Institutes of Health Research (Institute of Genetics) on "Genetic control of the development of dendrites."

Dr. Sal Carbonetto receives a three year grant from the Canadian Institutes of Health Research/Neuromuscular Research Partnership on "Dystroglycan function and dysfunction in the fly CNS."

June 2006

Dr. Sal Carbonetto receives a three year grant from the Muscular Dystrophy Association on "Dystroglycan in neuromuscular synapse formation."

CRN Publications

McDearmid JR, Liao M, Drapeau P. Glycine receptors regulate interneuron differentiation during spinal network development. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9679-84.

Mehaffey WH, Fernandez FR, Rashid AJ, Dunn RJ, Turner RW. Distribution and function of potassium channels in the electrosensory lateral line lobe of weakly electric apteronotid fish. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Jun;192(6):637-48.

Panatier A, Gentles SJ, Bourque CW, Oliet SH. Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus. J Physiol. 2006 Jun 15;573(Pt 3):711-21.

May 2006

CRN Publications

Brown CH, Leng G, Ludwig M, Bourque CW. Endogenous Activation of Supraoptic Nucleus {kappa}-Opioid Receptors Terminates Spontaneous Phasic Bursts in Rat Magnocellular Neurosecretory Cells. J Neurophysiol. 2006 May;95(5):3235-44.

Chakfe Y, Zhang Z, Bourque CW. IL-1beta directly excites isolated rat supraoptic neurons via upregulation of the osmosensory cation current. Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1183-90.

Tremblay MR, Carbonetto S. An extracellular pathway for dystroglycan function in acetylcholine receptor aggregation and laminin deposition in skeletal myotubes. J Biol Chem. 2006 May 12;281(19):13365-73.

April 2006

Dr. Yong Rao receives a Chercheurs-Boursiers (Senior Level) from the FRSQ on "Établissement de circuits neuronaux durant le développement"

CRN Publications

Cafferty P, Yu L, Long H, Rao Y. Semaphorin-1a functions as a guidance receptor in the Drosophila visual system. J Neurosci. 2006 Apr 12;26(15):3999-4003.

March 2006

CRN Publications

Long H, Cameron S, Yu L, Rao Y. De novo GMP synthesis is required for axon guidance in Drosophila. Genetics. 2006 Mar;172(3):1633-42.

Shah WA, Peng H, Carbonetto S. Role of non-raft cholesterol in lymphocytic choriomeningitis virus infection via alpha-dystroglycan. J Gen Virol. 2006 Mar;87(Pt 3):673-8.

Zhang Z, Bourque CW. Calcium permeability and flux through osmosensory transduction channels of isolated rat supraoptic nucleus neurons. Eur J Neurosci. 2006 Mar;23(6):1491-500.

February 2006

CRN Publications

Brown CH, Bourque CW. Mechanisms of rhythmogenesis: insights from hypothalamic vasopressin neurons. Trends Neurosci. 2006 Feb;29(2):108-15.

Stachniak TJ, Bourque CW. Visually guided whole cell patch clamp of mouse supraoptic nucleus neurons in cultured and acute conditions. Am J Physiol Regul Integr Comp Physiol. 2006 Feb 9.

January 2006

Dr. Samuel David receives a Proof of Principle Grant from the CIHR on "Pre-clinical testing of novel phospholipase A2 inhibitors for the treatment of multiple sclerosis"

Dr. Keith Murai receives a Scholar Research Award from The EJLB Foundation on "Characterizing dynamic neuron-glial interactions that regulate synapse structure and function"

CRN Publications

Haber M, Murai KK. Reshaping neuron-glial communication at hippocampal synapses. Neuron Glia Biology 2006 Jan;2:59-66.

McDearmid JR, Drapeau P. Rhythmic motor activity evoked by NMDA in the spinal zebrafish larva. J Neurophysiol. 2006 Jan;95(1):401-17.

Sharif Naeini R, Witty MF, Seguela P, Bourque CW. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci. 2006 Jan;9(1):93-8.

December 2005

CRN Publications

Deng Q, Rashid AJ, Fernandez FR, Turner RW, Maler L, Dunn RJ. A C-terminal domain directs Kv3.3 channels to dendrites. J Neurosci. 2005 Dec 14;25(50):11531-41.