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Philippe Gros Publications

Individual publications:  Philippe Gros

  1. Cai, J., V.L. Damaraju, N. Groulx, D. Mowles, Y. Peng, M.J. Robins, C.E. Cass, and P. Gros. 2008. Two distinct molecular mechanisms underlying cytarabine resistance in human leukemic cells. Cancer Res 68:2349-2357. PMID: 18381442
  2. Ayi, K., G. Min-Oo, L. Serghides, M. Crockett, M. Kirby-Allen, I. Quirt, P. Gros, and K.C. Kain. 2008. Pyruvate kinase deficiency and malaria. N Engl J Med 358:1805-1810. PMID: 18420493
  3. Dai, Y.D., I.G. Marrero, P. Gros, H. Zaghouani, L.S. Wicker, and E.E. Sercarz. 2009. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes 58:156-164. PMID: 18984740
  4. Faucher, S.P., C. Viau, P.P. Gros, F. Daigle, and H. Le Moual. 2008. The prpZ gene cluster encoding eukaryotic-type Ser/Thr protein kinases and phosphatases is repressed by oxidative stress and involved in Salmonella enterica serovar Typhi survival in human macrophages. FEMS Microbiol Lett 281:160-166. PMID: 18312574
  5. Patel, S.N., J. Berghout, F.E. Lovegrove, K. Ayi, A. Conroy, L. Serghides, G. Min-oo, D.C. Gowda, J.V. Sarma, D. Rittirsch, P.A. Ward, W.C. Liles, P. Gros, and K.C. Kain. 2008. C5 deficiency and C5a or C5aR blockade protects against cerebral malaria. J Exp Med 205:1133-1143. PMID: 18426986
  6. Valdez, Y., G.E. Diehl, B.A. Vallance, G.A. Grassl, J.A. Guttman, N.F. Brown, C.M. Rosenberger, D.R. Littman, P. Gros, and B.B. Finlay. 2008. Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Cell Microbiol 10:1646-1661. PMID: 18397382
  7. Zhang, A.S., F. Canonne-Hergaux, S. Gruenheid, P. Gros, and P. Ponka. 2008. Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Exp Hematol 36:1227-1235. PMID: 18722041
  8. Carrier, I., and P. Gros. 2008. Investigating the role of the invariant carboxylate residues E552 and E1197 in the catalytic activity of Abcb1a (mouse Mdr3). FEBS J 275:3312-3324. PMID: 18489584
  9. Divangahi, M., S. Mostowy, F. Coulombe, R. Kozak, L. Guillot, F. Veyrier, K.S. Kobayashi, R.A. Flavell, P. Gros, and M.A. Behr. 2008. NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J Immunol 181:7157-7165. PMID: 18981137
  10. Marquis, J.F., and P. Gros. 2008. Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J. Curr Top Microbiol Immunol 321:27-57. PMID: 18727486
  11. Marquis, J.F., A. Nantel, R. LaCourse, L. Ryan, R.J. North, and P. Gros. 2008. Fibrotic response as a distinguishing feature of resistance and susceptibility to pulmonary infection with Mycobacterium tuberculosis in mice. Infect Immun 76:78-88. PMID: 17938213
  12. Min-Oo, G., L. Lindqvist, A. Vaglenov, C. Wang, P. Fortin, Y. Li, B. Kaltenboeck, and P. Gros. 2008. Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse. Genes Immun 9:383-388. PMID: 18075514
  13. Torban, E., A.M. Patenaude, S. Leclerc, S. Rakowiecki, S. Gauthier, G. Andelfinger, D.J. Epstein, and P. Gros. 2008. Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A 105:3449-3454. PMID: 18296642
  14. Vidal, S.M., D. Malo, J.F. Marquis, and P. Gros. 2008. Forward genetic dissection of immunity to infection in the mouse. Annu Rev Immunol 26:81-132. PMID: 17953509
  15. Ayi, K., W.C. Liles, P. Gros, and K.C. Kain. 2009. Adenosine triphosphate depletion of erythrocytes simulates the phenotype associated with pyruvate kinase deficiency and confers protection against Plasmodium falciparum in vitro. J Infect Dis 200:1289-1299. PMID: 19743919
  16. Kibar, Z., C.M. Bosoi, M. Kooistra, S. Salem, R.H. Finnell, P. De Marco, E. Merello, A.G. Bassuk, V. Capra, and P. Gros. 2009. Novel mutations in VANGL1 in neural tube defects. Hum Mutat 30:E706-715. PMID: 19319979
  17. Schurr, E., and P. Gros. 2009. A common genetic fingerprint in leprosy and Crohn's disease? N Engl J Med 361:2666-2668. PMID: 20018963
  18. Valdez, Y., G.A. Grassl, J.A. Guttman, B. Coburn, P. Gros, B.A. Vallance, and B.B. Finlay. 2009. Nramp1 drives an accelerated inflammatory response during Salmonella-induced colitis in mice. Cell Microbiol 11:351-362. PMID: 19016783
  19. Bongfen, S.E., A. Laroque, J. Berghout, and P. Gros. 2009. Genetic and genomic analyses of host-pathogen interactions in malaria. Trends Parasitol 25:417-422. PMID: 19717339
  20. Czachorowski, M., S. Lam-Yuk-Tseung, M. Cellier, and P. Gros. 2009. Transmembrane topology of the mammalian Slc11a2 iron transporter. Biochemistry 48:8422-8434. PMID: 19621945
  21. Fortier, A., K. Doiron, M. Saleh, S. Grinstein, and P. Gros. 2009. Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4. Infect Immun 77:4794-4805. PMID: 19720760
  22. Marquis, J.F., R. Lacourse, L. Ryan, R.J. North, and P. Gros. 2009. Genetic and functional characterization of the mouse Trl3 locus in defense against tuberculosis. J Immunol 182:3757-3767. PMID: 19265154
  23. Marquis, J.F., R. LaCourse, L. Ryan, R.J. North, and P. Gros. 2009. Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IFN regulatory factor 8. J Immunol 182:3008-3015. PMID: 19234196
  24. Reynolds, A., J.R. McDearmid, S. Lachance, P. De Marco, E. Merello, V. Capra, P. Gros, P. Drapeau, and Z. Kibar. 2010. VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish. Mech Dev 127:385-392. PMID: 20043994
  25. Stevenson, M.M., P. Gros, M. Olivier, A. Fortin, and L. Serghides. 2010. Cerebral malaria: human versus mouse studies. Trends Parasitol 26:274-275. PMID: 20382077
  26. Behr, M., E. Schurr, and P. Gros. 2010. TB: screening for responses to a vile visitor. Cell 140:615-618. PMID: 20211131
  27. Berghout, J., G. Min-Oo, M. Tam, S. Gauthier, M.M. Stevenson, and P. Gros. 2010. Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes Immun 11:310-318. PMID: 19865103
  28. Dupaul-Chicoine, J., G. Yeretssian, K. Doiron, K.S. Bergstrom, C.R. McIntire, P.M. LeBlanc, C. Meunier, C. Turbide, P. Gros, N. Beauchemin, B.A. Vallance, and M. Saleh. 2010. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32:367-378. PMID: 20226691
  29. Gravel, M., A. Iliescu, C. Horth, S. Apuzzo, and P. Gros. 2010. Molecular and cellular mechanisms underlying neural tube defects in the loop-tail mutant mouse. Biochemistry 49:3445-3455. PMID: 20329788
  30. Gruenheid, S., and P. Gros. 2010. Forward genetic dissection of innate response to infection in inbred mouse strains: selected success stories. Clin Exp Immunol 162:393-401. PMID: 21070206
  31. Meunier, C., J. Cai, A. Fortin, T. Kwan, J.F. Marquis, C. Turbide, L. Van Der Kraak, S. Jothy, N. Beauchemin, and P. Gros. 2010. Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3. Oncogene 29:647-661. PMID: 19915610
  32. Min-Oo, G., K. Ayi, S.E. Bongfen, M. Tam, I. Radovanovic, S. Gauthier, H. Santiago, A.G. Rothfuchs, E. Roffe, A. Sher, A. Mullick, A. Fortin, M.M. Stevenson, K.C. Kain, and P. Gros. 2010. Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium. Exp Parasitol 125:315-324. PMID: 20219464
  33. Min-Oo, G., A. Fortin, J.F. Poulin, and P. Gros. 2010. Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin. Antimicrob Agents Chemother 54:3262-3270. PMID: 20479197
  34. Min-Oo, G., A. Willemetz, M. Tam, F. Canonne-Hergaux, M.M. Stevenson, and P. Gros. 2010. Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9. Genes Immun 11:113-123. PMID: 19865104
  35. Murawski, I.J., R.W. Maina, D. Malo, L.M. Guay-Woodford, P. Gros, M. Fujiwara, K. Morgan, and I.R. Gupta. 2010. The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12. In Kidney Int. 269-278. PMID: 20407478
  36. Van Der Kraak, L., C. Meunier, C. Turbide, S. Jothy, L. Gaboury, V. Marcus, S.Y. Chang, N. Beauchemin, and P. Gros. 2010. A two-locus system controls susceptibility to colitis-associated colon cancer in mice. Oncotarget 1:436-446. PMID: 21311099
  37. Kibar, Z., S. Salem, C.M. Bosoi, E. Pauwels, P. De Marco, E. Merello, A.G. Bassuk, V. Capra, and P. Gros. 2011. Contribution of VANGL2 mutations to isolated neural tube defects. Clin Genet 80:76-82. PMID: 20738329
  38. Longley, R., C. Smith, A. Fortin, J. Berghout, B. McMorran, G. Burgio, S. Foote, and P. Gros. 2011. Host resistance to malaria: using mouse models to explore the host response. Mamm Genome 22:32-42. PMID: 21116636
  39. Fortier, A., S.P. Faucher, K. Diallo, and P. Gros. 2011. Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages. Immunobiology 216:1274-1285. PMID: 21794945
  40. Hambleton, S., S. Salem, J. Bustamante, V. Bigley, S. Boisson-Dupuis, J. Azevedo, A. Fortin, M. Haniffa, L. Ceron-Gutierrez, C.M. Bacon, G. Menon, C. Trouillet, D. McDonald, P. Carey, F. Ginhoux, L. Alsina, T.J. Zumwalt, X.F. Kong, D. Kumararatne, K. Butler, M. Hubeau, J. Feinberg, S. Al-Muhsen, A. Cant, L. Abel, D. Chaussabel, R. Doffinger, E. Talesnik, A. Grumach, A. Duarte, K. Abarca, D. Moraes-Vasconcelos, D. Burk, A. Berghuis, F. Geissmann, M. Collin, J.L. Casanova, and P. Gros. 2011. IRF8 mutations and human dendritic-cell immunodeficiency. N Engl J Med 365:127-138. PMID: 21524210
  41. Iliescu, A., M. Gravel, C. Horth, S. Apuzzo, and P. Gros. 2011. Transmembrane topology of mammalian planar cell polarity protein Vangl1. Biochemistry 50:2274-2282. PMID: 21291170
  42. Iliescu, A., M. Gravel, C. Horth, Z. Kibar, and P. Gros. 2011. Loss of membrane targeting of Vangl proteins causes neural tube defects. Biochemistry 50:795-804. PMID: 21142127
  43. Marquis, J.F., O. Kapoustina, D. Langlais, R. Ruddy, C.R. Dufour, B.H. Kim, J.D. MacMicking, V. Giguere, and P. Gros. 2011. Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis. PLoS Genet 7:e1002097. PMID: 21731497
  44. Meunier, C., T. Kwan, C. Turbide, N. Beauchemin, and P. Gros. 2011. Genetic control of susceptibility to carcinogen-induced colorectal cancer in mice: the Ccs3 and Ccs5 loci regulate different aspects of tumorigenesis. Cell Cycle 10:1739-1749. PMID: 21543896
  45. Min-Oo, G., and P. Gros. 2011. Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria. Mamm Genome 22:486-494. PMID: 21437649
  46. Moreno, Y., P.P. Gros, M. Tam, M. Segura, R. Valanparambil, T.G. Geary, and M.M. Stevenson. 2011. Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information. PLoS Negl Trop Dis 5:e1370. PMID: 22039562
  47. Radovanovic, I., A. Mullick, and P. Gros. 2011. Genetic control of susceptibility to infection with Candida albicans in mice. PLoS One 6:e18957. PMID: 21533108
  48. Seo, J.H., Y. Zilber, S. Babayeva, J. Liu, P. Kyriakopoulos, P. De Marco, E. Merello, V. Capra, P. Gros, and E. Torban. 2011. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. Hum Mol Genet 20:4324-4333. PMID: 21840926
  49. Guyot, M.C., C.M. Bosoi, F. Kharfallah, A. Reynolds, P. Drapeau, M. Justice, P. Gros, and Z. Kibar. 2011. A novel hypomorphic Looptail allele at the planar cell polarity Vangl2 gene. Dev Dyn 240:839-849. PMID: 21404367
  50. Mullick, A., J. Tremblay, Z. Leon, and P. Gros. 2011. A novel role for the fifth component of complement (C5) in cardiac physiology. PLoS One 6:e22919. PMID: 21829669
  51. Ramirez-Aquino, R., I. Radovanovic, A. Fortin, E. Sciutto-Conde, G. Fragoso-Gonzalez, P. Gros, and I. Aguilar-Delfin. 2011. Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis. PLoS Negl Trop Dis 5:e1435. PMID: 22206032
  52. Berghout, J., S. Higgins, C. Loucoubar, A. Sakuntabhai, K.C. Kain, and P. Gros. 2012. Genetic diversity in human erythrocyte pyruvate kinase. Genes Immun 13:98-102. PMID: 21833022
  53. Bogunovic, D., M. Byun, L.A. Durfee, A. Abhyankar, O. Sanal, D. Mansouri, S. Salem, I. Radovanovic, A.V. Grant, P. Adimi, N. Mansouri, S. Okada, V.L. Bryant, X.F. Kong, A. Kreins, M.M. Velez, B. Boisson, S. Khalilzadeh, U. Ozcelik, I.A. Darazam, J.W. Schoggins, C.M. Rice, S. Al-Muhsen, M. Behr, G. Vogt, A. Puel, J. Bustamante, P. Gros, J.M. Huibregtse, L. Abel, S. Boisson-Dupuis, and J.L. Casanova. 2012. Mycobacterial disease and impaired IFN-gamma immunity in humans with inherited ISG15 deficiency. Science 337:1684-1688. PMID: 22859821
  54. Idaghdour, Y., J. Quinlan, J.P. Goulet, J. Berghout, E. Gbeha, V. Bruat, T. de Malliard, J.C. Grenier, S. Gomez, P. Gros, M.C. Rahimy, A. Sanni, and P. Awadalla. 2012. Evidence for additive and interaction effects of host genotype and infection in malaria. Proc Natl Acad Sci U S A 109:16786-16793. PMID: 22949651
  55. Bongfen, S.E., I.G. Rodrigue-Gervais, J. Berghout, S. Torre, P. Cingolani, S.A. Wiltshire, G.A. Leiva-Torres, L. Letourneau, R. Sladek, M. Blanchette, M. Lathrop, M.A. Behr, S. Gruenheid, S.M. Vidal, M. Saleh, and P. Gros. 2012. An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria. PLoS One 7:e31012. PMID: 22363534
  56. Laroque, A., G. Min-Oo, M. Tam, I. Radovanovic, M.M. Stevenson, and P. Gros. 2012. Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains. Genes Immun 13:155-163. PMID: 21975430
  57. Torban, E., A. Iliescu, and P. Gros. 2012. An expanding role of Vangl proteins in embryonic development. Curr Top Dev Biol 101:237-261. PMID: 23140632
  58. Byun, M., C.S. Ma, A. Akcay, V. Pedergnana, U. Palendira, J. Myoung, D.T. Avery, Y. Liu, A. Abhyankar, L. Lorenzo, M. Schmidt, H.K. Lim, O. Cassar, M. Migaud, F. Rozenberg, N. Canpolat, G. Aydogan, B. Fleckenstein, J. Bustamante, C. Picard, A. Gessain, E. Jouanguy, E. Cesarman, M. Olivier, P. Gros, L. Abel, M. Croft, S.G. Tangye, and J.L. Casanova. 2013. Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med 210:1743-1759. PMID: 23897980
  59. Berghout, J., D. Langlais, I. Radovanovic, M. Tam, J.D. MacMicking, M.M. Stevenson, and P. Gros. 2013. Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. PLoS Pathog 9:e1003491. PMID: 23853600
  60. Meunier, C., L. Van Der Kraak, C. Turbide, N. Groulx, I. Labouba, P. Cingolani, M. Blanchette, G. Yeretssian, A.M. Mes-Masson, M. Saleh, N. Beauchemin, and P. Gros. 2013. Positional mapping and candidate gene analysis of the mouse Ccs3 locus that regulates differential susceptibility to carcinogen-induced colorectal cancer. PLoS One 8:e58733. PMID: 23516545
  61. Salem, S., and P. Gros. 2013. Genetic determinants of susceptibility to Mycobacterial infections: IRF8, a new kid on the block. Adv Exp Med Biol 783:45-80. PMID: 23468103
  62. Torre, S., R. van Bruggen, J.M. Kennedy, J. Berghout, S.E. Bongfen, P. Langat, M. Lathrop, S.M. Vidal, and P. Gros. 2013. Susceptibility to lethal cerebral malaria is regulated by epistatic interaction between chromosome 4 (Berr6) and chromosome 1 (Berr7) loci in mice. Genes Immun 14:249-257. PMID: 23594960
  63. Caignard, G., M.M. Eva, R. van Bruggen, R. Eveleigh, G. Bourque, D. Malo, P. Gros, and S.M. Vidal. 2014. Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives. Genes (Basel) 5:887-925. PMID: 25268389
  64. Dauphinee, S.M., E. Richer, M.M. Eva, F. McIntosh, M. Paquet, D. Dangoor, C. Burkart, D.E. Zhang, S. Gruenheid, P. Gros, M. Behr, and D. Malo. 2014. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. Genes Immun 15:282-292. PMID: 24807690
  65. Gros, P., and Y. Belkaid. 2014. Editorial overview: Host pathogens. Curr Opin Immunol 29:iv-vi. PMID: 25027097
  66. Iliescu, A., M. Gravel, C. Horth, and P. Gros. 2014. Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting. Biochemistry 53:5356-5364. PMID: 25068569
  67. Iliescu, A., and P. Gros. 2014. The intracellular carboxyl terminal domain of Vangl proteins contains plasma membrane targeting signals. Protein Sci 23:337-343. PMID: 24452931
  68. Kennedy, J.M., N. Fodil, S. Torre, S.E. Bongfen, J.F. Olivier, V. Leung, D. Langlais, C. Meunier, J. Berghout, P. Langat, J. Schwartzentruber, J. Majewski, M. Lathrop, S.M. Vidal, and P. Gros. 2014. CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation. J Exp Med 10.1084/jem.20140455:PMID: 25403443
  69. Meadows, D.N., M. Pyzik, Q. Wu, S. Torre, P. Gros, S.M. Vidal, and R. Rozen. 2014. Increased resistance to malaria in mice with methylenetetrahydrofolate reductase (Mthfr) deficiency suggests a mechanism for selection of the MTHFR 677C>T (c.665C>T) variant. Hum Mutat 35:594-600. PMID: 24616178
  70. Radovanovic, I., V. Leung, A. Iliescu, S.E. Bongfen, A. Mullick, D. Langlais, and P. Gros. 2014. Genetic control of susceptibility to Candida albicans in SM/J mice. J Immunol 193:1290-1300. PMID: 24973457
  71. Rocque, B.L., S. Babayeva, J. Li, V. Leung, L. Nezvitsky, A.V. Cybulsky, P. Gros, and E. Torban. 2014. Deficiency of the Planar Cell Polarity Protein Vangl2 in Podocytes Affects Glomerular Morphogenesis and Increases Susceptibility to Injury. J Am Soc Nephrol 10.1681/ASN.2014040340:PMID: 25145929
  72. Salem, S., C. Gao, A. Li, H. Wang, L. Nguyen-Yamamoto, D. Goltzman, J.E. Henderson, and P. Gros. 2014. A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism. J Cell Mol Med 18:1588-1598. PMID: 24954358
  73. Salem, S., D. Langlais, F. Lefebvre, G. Bourque, V. Bigley, M. Haniffa, J.L. Casanova, D. Burk, A. Berghuis, K.M. Butler, T.R. Leahy, S. Hambleton, and P. Gros. 2014. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation. Blood 10.1182/blood-2014-04-570879:PMID: 25122610
  74. Zhang, X., D. Bogunovic, B. Payelle-Brogard, V. Francois-Newton, S.D. Speer, C. Yuan, S. Volpi, Z. Li, O. Sanal, D. Mansouri, I. Tezcan, G.I. Rice, C. Chen, N. Mansouri, S.A. Mahdaviani, Y. Itan, B. Boisson, S. Okada, L. Zeng, X. Wang, H. Jiang, W. Liu, T. Han, D. Liu, T. Ma, B. Wang, M. Liu, J.Y. Liu, Q.K. Wang, D. Yalnizoglu, L. Radoshevich, G. Uze, P. Gros, F. Rozenberg, S.Y. Zhang, E. Jouanguy, J. Bustamante, A. Garcia-Sastre, L. Abel, P. Lebon, L.D. Notarangelo, Y.J. Crow, S. Boisson-Dupuis, J.L. Casanova, and S. Pellegrini. 2014. Human intracellular ISG15 prevents interferon-alpha/beta over-amplification and auto-inflammation. Nature 10.1038/nature13801:PMID: 25307056

Publications (complete list) - Philippe Gros