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The laboratory of Philippe Gros (Department of Biochemistry, Human Genetics) uses a genetic approach in mouse models of infection with Mycobacterium tuberculosis (tuberculosis), Plasmodium chabaudi (blood stage malaria), Plasmodium berghei (cerebral malaria), and Candida albicans to identify host genes and proteins that affect onset, progression and outcome of these infections.  The mouse genetic discovery platforms include inbred mouse strains, AcB/BcA recombinant congenic strains and ENU chemical mutagenesis (with other members of the group).  Gene mutations discovered in mice as affecting susceptibility to infections are validated in clinical specimens from humans living in endemic areas of diseases and/or in rare patients suffering of specific non-syndromic immunodeficiencies.  Genes and proteins being studied include the phagosomal iron transporter Slc11a1 (Nramp1), the bacterial flagellin intracellular sensor of macrophages Birc1e (Naip5), and master myeloid and lymphoid transcriptional regulators IRF1, IRF8, and STAT1. We are also developing bioinformatic tools to analyze rare and common variants identified in cohorts of unique patients suffering from acute infections or chronic inflammatory conditions, for enrichment of variants in genes regulated by these pro-inflammatory transcription factors.

Gros Lab Contact Information

Contact Information:
Office Phone: (514) 398-7291
Lab Phone:  (514) 398-2542
Fax: (514) 398-2603
Email: philippe [dot] gros [at] mcgill [dot] ca

Mailing address:
McGill Life Sciences Complex
Bellini Pavilion, Room 366
3649 Promenade Sir-William Osler
Montreal, Qc, Canada H3G 0B1