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Anastasia Nijnik Publications

Individual publications:  Ana Nijnik

  1. Easton, D.M., A. Nijnik, M.L. Mayer, and R.E. Hancock. 2009. Potential of immunomodulatory host defense peptides as novel anti-infectives. Trends Biotechnol 27:582-590. PMID: 19683819
  2. Kindrachuk, J., H. Jenssen, M. Elliott, R. Townsend, A. Nijnik, S.F. Lee, V. Gerdts, L.A. Babiuk, S.A. Halperin, and R.E. Hancock. 2009. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine 27:4662-4671. PMID: 19539585
  3. Mookherjee, N., D.N. Lippert, P. Hamill, R. Falsafi, A. Nijnik, J. Kindrachuk, J. Pistolic, J. Gardy, P. Miri, M. Naseer, L.J. Foster, and R.E. Hancock. 2009. Intracellular receptor for human host defense peptide LL-37 in monocytes. J Immunol 183:2688-2696. PMID: 19605696
  4. Nijnik, A., S. Dawson, T.L. Crockford, L. Woodbine, S. Visetnoi, S. Bennett, M. Jones, G.D. Turner, P.A. Jeggo, C.C. Goodnow, and R.J. Cornall. 2009. Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. J Clin Invest 119:1696-1705. PMID: 19451691
  5. Nijnik, A., and R. Hancock. 2009. Host defence peptides: antimicrobial and immunomodulatory activity and potential applications for tackling antibiotic-resistant infections. Emerg Health Threats J 2:e1. PMID: 22460279
  6. Nijnik, A., and R.E. Hancock. 2009. The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr Opin Hematol 16:41-47. PMID: 19068548
  7. Nijnik, A., J. Pistolic, A. Wyatt, S. Tam, and R.E. Hancock. 2009. Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs. J Immunol 183:5788-5798. PMID: 19812202
  8. Nijnik, A., L. Madera, S. Ma, M. Waldbrook, M.R. Elliott, D.M. Easton, M.L. Mayer, S.C. Mullaly, J. Kindrachuk, H. Jenssen, and R.E. Hancock. 2010. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol 184:2539-2550. PMID: 20107187
  9. Amatngalim, G.D., A. Nijnik, P.S. Hiemstra, and R.E. Hancock. 2011. Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds. Inflammation 34:412-425. PMID: 20811938
  10. Diehl, A.D., A.D. Augustine, J.A. Blake, L.G. Cowell, E.S. Gold, T.A. Gondre-Lewis, A.M. Masci, T.F. Meehan, P.A. Morel, A. Nijnik, B. Peters, B. Pulendran, R.H. Scheuermann, Q.A. Yao, M.S. Zand, and C.J. Mungall. 2011. Hematopoietic cell types: prototype for a revised cell ontology. J Biomed Inform 44:75-79. PMID: 20123131
  11. Hancock, R.E., A. Nijnik, and D.J. Philpott. 2012. Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol 10:243-254. PMID: 22421877
  12. Nijnik, A., S. Clare, C. Hale, J. Chen, C. Raisen, L. Mottram, M. Lucas, J. Estabel, E. Ryder, H. Adissu, P. Sanger Mouse Genetics, N.C. Adams, R. Ramirez-Solis, J.K. White, K.P. Steel, G. Dougan, and R.E. Hancock. 2012. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol 189:102-111. PMID: 22664872
  13. Nijnik, A., S. Clare, C. Hale, C. Raisen, R.E. McIntyre, K. Yusa, A.R. Everitt, L. Mottram, C. Podrini, M. Lucas, J. Estabel, D. Goulding, F. Sanger Institute Microarray, P. Sanger Mouse Genetics, N. Adams, R. Ramirez-Solis, J.K. White, D.J. Adams, R.E. Hancock, and G. Dougan. 2012. The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation. Blood 119:1370-1379. PMID: 22184403
  14. Nijnik, A., J. Pistolic, P. Cho, N.C. Filewod, R. Falsafi, A. Ramin, K.W. Harder, and R.E. Hancock. 2012. The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells. J Leukoc Biol 91:599-607. PMID: 22246800
  15. Nijnik, A., J. Pistolic, N.C. Filewod, and R.E. Hancock. 2012. Signaling pathways mediating chemokine induction in keratinocytes by cathelicidin LL-37 and flagellin. J Innate Immun 4:377-386. PMID: 22516952
  16. Kindrachuk, J., H. Jenssen, M. Elliott, A. Nijnik, L. Magrangeas-Janot, M. Pasupuleti, L. Thorson, S. Ma, D.M. Easton, M. Bains, B. Finlay, E.J. Breukink, H. Georg-Sahl, and R.E. Hancock. 2013. Manipulation of innate immunity by a bacterial secreted peptide: lantibiotic nisin Z is selectively immunomodulatory. Innate Immun 19:315-327. PMID: 23109507
  17. Nijnik, A. 2013. Immunomodulatory approaches for prevention and treatment of infectious diseases. Curr Opin Microbiol 16:590-595. PMID: 23870826
  18. Belle, J.I., D. Langlais, P. Gros, R.G. Jones, M. Pardo, and A. Nijnik. 2014. Histone H2A Deubiquitinase MYSM1 Represses P53 Pathway Activity in the Hematopoietic System. In revision, Blood
  19. Belle, J.I., and A. Nijnik. 2014. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Int J Biochem Cell Biol 50:161-174. PMID: 24647359
  20. Chen, J., N. Ingham, J. Kelly, S. Jadeja, D. Goulding, J. Pass, V.B. Mahajan, S.H. Tsang, A. Nijnik, I.J. Jackson, J.K. White, A. Forge, D. Jagger, and K.P. Steel. 2014. Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. PLoS Genet 10:e1004688. PMID: 25356849
  21. Pannu, J., J.I. Belle, M. Forster, C. Duerr, L. Kane, K. Harcourt, J.H. Fritz, S. Clare, and A. Nijnik. 2014. Ubiquitin Specific Protease 21 is Dispensable for Normal Development, Hematopoiesis and Immunity. . In revision for resubmission to PLoS One
  22. You, L., J. Zhou, J.I. Belle, A. Nijnik, E. Wang, and X.J. Yang. 2014. Acute bone marrow failure and congenital hematopoietic stem/progenitor cell defects in Brpf1-deficient mice. Submitted to Nat Med

Publications (complete list)- Ana Nijnik