Anastasia Nijnik Publications

Modulating immunity as a therapy for bacterial infections.

Hancock RE, Nijnik A, Philpott DJ.

Nat Rev Microbiol. 2012 Mar 16;10(4):243-54. doi: 10.1038/nrmicro2745.

PMID:: 22421877; [PubMed - in process]

The role of the Src family kinase Lyn in the immunomodulatory activities of cathelicidin peptide LL-37 on monocytic cells.

Nijnik A, Pistolic J, Cho P, Filewod NC, Falsafi R, Ramin A, Harder KW, Hancock RE.

J Leukoc Biol. 2012 Jan 13. [Epub ahead of print]

PMID:: 22246800; [PubMed - as supplied by publisher]

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The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.

Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D; Sanger Institute Microarray Facility; Sanger Mouse Genetics Project, Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G.

Blood. 2012 Feb 9;119(6):1370-9. Epub 2011 Dec 19.

PMID:: 22184403; [PubMed - in process]

Free PMC Article

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Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds.

Amatngalim GD, Nijnik A, Hiemstra PS, Hancock RE.

Inflammation. 2011 Oct;34(5):412-25. doi: 10.1007/s10753-010-9248-6.

PMID:: 20811938; [PubMed - indexed for MEDLINE]

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Hematopoietic cell types: prototype for a revised cell ontology.

Diehl AD, Augustine AD, Blake JA, Cowell LG, Gold ES, Gondré-Lewis TA, Masci AM, Meehan TF, Morel PA, Nijnik A, Peters B, Pulendran B, Scheuermann RH, Yao QA, Zand MS, Mungall CJ.

J Biomed Inform. 2011 Feb;44(1):75-9. Epub 2010 Feb 1.

PMID:: 20123131; [PubMed - indexed for MEDLINE]

Free PMC Article

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Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment.

Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE.

J Immunol. 2010 Mar 1;184(5):2539-50. Epub 2010 Jan 27.

PMID:: 20107187; [PubMed - indexed for MEDLINE]

Free Article

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Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs.

Nijnik A, Pistolic J, Wyatt A, Tam S, Hancock RE.

J Immunol. 2009 Nov 1;183(9):5788-98. Epub 2009 Oct 7.

PMID:: 19812202; [PubMed - indexed for MEDLINE]

Free Article

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Potential of immunomodulatory host defense peptides as novel anti-infectives.

Easton DM, Nijnik A, Mayer ML, Hancock RE.

Trends Biotechnol. 2009 Oct;27(10):582-90. Epub 2009 Aug 14. Review.

PMID:: 19683819; [PubMed - indexed for MEDLINE]

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Intracellular receptor for human host defense peptide LL-37 in monocytes.

Mookherjee N, Lippert DN, Hamill P, Falsafi R, Nijnik A, Kindrachuk J, Pistolic J, Gardy J, Miri P, Naseer M, Foster LJ, Hancock RE.

J Immunol. 2009 Aug 15;183(4):2688-96. Epub 2009 Jul 15.

PMID:: 19605696; [PubMed - indexed for MEDLINE]

Free Article

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10.

A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity.

Kindrachuk J, Jenssen H, Elliott M, Townsend R, Nijnik A, Lee SF, Gerdts V, Babiuk LA, Halperin SA, Hancock RE.

Vaccine. 2009 Jul 23;27(34):4662-71. Epub 2009 Jun 17.

PMID:: 19539585; [PubMed - indexed for MEDLINE]

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11.

Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome.

Nijnik A, Dawson S, Crockford TL, Woodbine L, Visetnoi S, Bennett S, Jones M, Turner GD, Jeggo PA, Goodnow CC, Cornall RJ.

J Clin Invest. 2009 Jun;119(6):1696-705. doi: 10.1172/JCI32743. Epub 2009 May 18.

PMID:: 19451691; [PubMed - indexed for MEDLINE]

Free PMC Article

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12.

The roles of cathelicidin LL-37 in immune defences and novel clinical applications.

Nijnik A, Hancock RE.

Curr Opin Hematol. 2009 Jan;16(1):41-7. Review.

PMID:: 19068548; [PubMed - indexed for MEDLINE]

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13.

DNA repair is limiting for haematopoietic stem cells during ageing.

Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ.

Nature. 2007 Jun 7;447(7145):686-90.