(BSc, MSc California State, PhD Wesleyan Univ.)
Macdonald Campus, McGill University
21,111 Lakeshore Road
Ste. Anne de Bellevue,
Quebec H9X 3V9
reza [dot] salavati [at] mcgill [dot] ca (Email)
My research is focused on the fundamental molecular aspects of three related trypanosomatid pathogens, together known as the Tritryps: Trypanosoma brucei group, T. cruzi, and Leishmania species. Respectively, these species cause African sleeping sickness (and related diseases in animals), Chagas’ disease and Leishmaniasis.
The availability of the completed genome sequences (http://www.genedb.org/) for these three pathogens provides a basis for a better understanding of the genetic mechanisms and evolutionary events which have shaped both the common and distinct aspects of their life styles. In addition, the genome sequences provide a substantial opportunity for the identification of novel potential drug targets through bioinformatics and database mining.
Moshiri H, Acoca S, Kala S, Najafabadi HS, Hogues H, Purisima E, Salavati R.
Naphthalene-based RNA editing inhibitor blocks RNA editing activities and editosome assembly in Trypanosoma brucei. J Biol Chem. 2011 Apr 22;286(16):14178-89. Epub 2011 Mar 4.
Shateri Najafabadi H, Salavati R.
Functional genome annotation by combined analysis across microarray studies of Trypanosoma brucei. PLoS Negl Trop Dis. 2010 Aug 31;4(8). pii: e810.
Kala S, Salavati R.
OB-fold domain of KREPA4 mediates high-affinity interaction with guide RNA and possesses annealing activity. RNA. 2010 Oct;16(10):1951-67. Epub 2010 Aug 16.
Moshiri H, Salavati R.
A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens. Nucleic Acids Res. 2010 Jul;38(13):e138. Epub 2010 May 5.
Salavati R, Najafabadi HS.
Sequence-based functional annotation: what if most of the genes are unique to a genome? Trends Parasitol. 2010 May;26(5):225-9. Epub 2010 Mar 6. Review.
Najafabadi HS, Goodarzi H, Salavati R.
Universal function-specificity of codon usage. Nucleic Acids Res. 2009 Nov;37(21):7014-23.
Mao Y, Najafabadi HS, Salavati R.
Genome-wide computational identification of functional RNA elements in Trypanosoma brucei. BMC Genomics. 2009 Aug 4;10:355.
Shaneh A, Salavati R.
Kinetoplastid RNA editing ligases 1 and 2 exhibit different electrostatic properties. J Mol Model. 2009 May 27. [Epub ahead of print]