Assistant Professor and Canada Research Chair (CRC)
Lyman Duff Medical Building, McGill University
3775 University St.,
Montreal, QC H3A 2B4
Research efforts are focused on the investigation of the immune regulation of autoimmune and infectious diseases mediated by CD4+CD25+ regulatory T (Treg) cells. CD4+CD25+ Treg cells represent a unique subset of peripheral CD4+ T cells mediating peripheral immunological tolerance. The laboratory uses an array of experimental approaches including cell and molecular biology, imaging, proteomics, genomics, animal models and clinical research to understand the mechanisms by which CD4+CD25+ Treg cells dampen inflammation and immune function. This research may lead to the development of novel therapeutic strategies to manipulate T cell regulatory activity in autoimmune and chronic inflammatory diseases.Immunology, autoimmune diseases, infectious disease, diabetes, regulatory T cells, immunosuppression, imaging, proteomics, genomics.
Kornete M, Sgouroudis E, Piccirillo CA.
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol. 2012 Feb 1;188(3):1064-74. Epub 2012 Jan 6.
Vinh DC, Bin Dhuban K, Mason H, Lejtenyi D, Jung S, Sheppard DC, Faury D, Jabado N, Piccirillo CA.
Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin. Clin Vaccine Immunol. 2012 Jan;19(1):109-12. Epub 2011 Nov 16.
Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R.
Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res. 2011 Nov 15;17(22):6985-91. Epub 2011 Nov 8.
Hardenberg G, Yao Y, Piccirillo CA, Levings MK, Steiner TS.
Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflamm Bowel Dis. 2012 Jan;18(1):85-93. doi: 10.1002/ibd.21738. Epub 2011 Oct 29.
Yurchenko E, Levings MK, Piccirillo CA.
CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol. 2011 Dec;41(12):3455-66. doi: 10.1002/eji.201141814. Epub 2011 Nov 10.
Kornete M, Piccirillo CA.
Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I diabetes. Autoimmun Rev. 2011 Dec;11(2):104-11. Epub 2011 Aug 22.
Grange C, Létourneau J, Forget MA, Godin-Ethier J, Martin J, Liberman M, Latour M, Widmer H, Lattouf JB, Piccirillo CA, Cailhier JF, Lapointe R.
Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation.J Immunol Methods. 2011 Sep 30;372(1-2):119-26. Epub 2011 Jul 18.
Bahcheli D, Hay V, Nadeau JL, Piccirillo CA.
Transfer of cell membrane components via trogocytosis occurs in CD4+ Foxp3+ CD25+ regulatory T-cell contact-dependent suppression. Autoimmunity. 2011 Dec;44(8):607-15. Epub 2011 May 23.