21,111 Lakeshore Road
Ste. Anne de Bellevue, Qc, H9X 3V9
armando [dot] jardim [at] mcgill [dot] ca (Email)
Leishmania and related trypanosomatids have a specialized organelle called a glycosome that compartmentalizes enzymes essential for a variety of enzymes essential for metabolic processes such as glycolysis, fatty acid b-oxidation, purine salvage, pyrimidine biosynthesis, lipid biosynthesis, and carbon dioxide fixation. These glycosomal proteins are synthesized in the cytosolic and imported across the glycosome membrane by a yet unknown mechanism. My lab uses a multidisciplinary approach that exploits protein chemistry, bioinformatics, molecular biology, immunocytochemistry, and genetic techniques to investigated the molecular processes involved in the targeting and import of proteins into the glycosome. An ultimate goal of this work is to identify potential protein targets that may be used to develop new antiparasitic chemotherapeutic agents.