Canada Research Chair in Parasite Biotechnology
21,111 Lakeshore Road
Ste. Anne de Bellevue, Quebec H9X 3V9
My appointment in the Institute of Parasitology is effective in September 2005. Coming from a 20-year career in the pharmaceutical industry, I bring to McGill a strong background in drug discovery and in all aspects of the pharmacology of antiparasitic drugs. This work included the molecular identification of drug targets through functional genomic analysis of nematode physiology and the subsequent engineering of recombinant systems for high-throughput screening for new antiparasitic leads.
I intend to continue research on drug targets in parasites and on the chemotherapy of antiparasitic drugs. In addition, my interests include basic work on the proteins secreted by parasites and hosts that determine the success of infection. Proteomic analysis of the ‘secretome’ of filarial parasites, and the manner in which drugs such as ivermectin affect the secretome, will be a focus of my research. This program will encompass in time both protozoal and nematode parasites of human and veterinary importance and will include international collaborators.
Geary TG, Bourguinat C, Prichard RK.
Evidence for macrocyclic lactone anthelmintic resistance in Dirofilaria immitis. Top Companion Anim Med. 2011 Nov;26(4):186-92. Review.
Geary TG, Moreno Y.
Macrocyclic Lactone Anthelmintics: Spectrum Of Activity And Mechanism Of Action. Curr Pharm Biotechnol. 2011 Oct 31. [Epub ahead of print]
Moreno Y, Gros PP, Tam M, Segura M, Valanparambil R, Geary TG, Stevenson MM.
Proteomic analysis of excretory-secretory products of Heligmosomoides polygyrus assessed with next-generation sequencing transcriptomic information. PLoS Negl Trop Dis. 2011 Oct;5(10):e1370. Epub 2011 Oct 25.
Geary TG, Mackenzie CD.
Progress and challenges in the discovery of macrofilaricidal drugs. Expert Rev Anti Infect Ther. 2011 Aug;9(8):681-95. Review.
Mackenzie CD, Geary TG.
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. Expert Rev Anti Infect Ther. 2011 May;9(5):497-501.
Bourguinat C, Keller K, Prichard RK, Geary TG.
Genetic polymorphism in Dirofilaria immitis. Vet Parasitol. 2011 Mar 22;176(4):368-73. Epub 2011 Jan 19.
Bourguinat C, Keller K, Blagburn B, Schenker R, Geary TG, Prichard RK.
Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype. Vet Parasitol. 2011 Mar 22;176(4):374-81. Epub 2011 Jan 19.
Ruiz-Lancheros E, Viau C, Walter TN, Francis A, Geary TG.
Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. Int J Parasitol. 2011 Mar;41(3-4):455-61. Epub 2010 Dec 30.