Otto Maass Chemistry Building, McGill University
801 Sherbrooke Street West
Montreal, Quebec H3A 2K6
Among the central tenants of Chemical Biology is that new chemistry can be learned by a careful examination of biology at the extremes. Parasites by definition live at the extreme of the manifold of host/guest interactions and it is not surprising that their biochemistry often attains high levels of sophistication. We are currently engaged in projects to understand the unique heme metabolism exhibited by Plasmodia during the malaria infection of redblood cells. To this end we have solved the structure of the heme by-product and determined the fundamental chemistry of its crystal growth and interaction with antimalarial drugs. In addition to this avenue of research we also have substantial NSERC support for research into the chemical biology of nitric oxide and other immunoinorganic cytotoxins.
Pinter TB, Dodd EL, Bohle DS, Stillman MJ.
Spectroscopic and Theoretical Studies of Ga(III)protoporphyrin-IX and Its Reactions with Myoglobin. Inorg Chem. 2012 Feb 28. Epub ahead of print.
Fotie J, Kemami Wangun HV, Fronczek FR, Massawe N, Bhattarai BT, Rhodus JL, Singleton TA, Bohle DS.
Unexpected 5,6,7,8,9,10-Hexahydro-6,6-pentamethylenephenanthridines and 2,3,4,5-Tetrahydro-4,4-tetramethylene-1H-cyclopenta[c]quinolines from Skraup-Doebner-Von Miller Quinoline Synthesis and Their Implications for the Mechanism of That Reaction. J Org Chem. 2012 Feb 28. Epub ahead of print.
Asghari-Khiavi M, Vongsvivut J, Perepichka I, Mechler A, Wood BR, McNaughton D, Bohle DS.
Interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX, a solid state spectroscopy study. J Inorg Biochem. 2011 Dec;105(12):1662-9. Epub 2011 Aug 12.
Bohle DS, Dodd EL, Kosar AJ, Sharma L, Stephens PW, Suárez L, Tazoo D.
Soluble synthetic analogues of malaria pigment: structure of mesohematin anhydride and its interaction with chloroquine in solution. Angew Chem Int Ed Engl. 2011 Jun 27;50(27):6151-4. doi: 10.1002/anie.201100910. Epub 2011 May 3.
Walczak MS, Lawniczak-Jablonska K, Wolska A, Sikora M, Sienkiewicz A, Suárez L, Kosar AJ, Bellemare MJ, Bohle DS.
Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution. J Phys Chem B. 2011 Apr 21;115(15):4419-26. Epub 2011 Mar 24.
Bohle DS, Chua Z.
N-H activation in N-nitropropionamide: coordination chemistry of a primary nitroamide. Inorg Chem. 2011 Apr 4;50(7):3135-40. Epub 2011 Mar 10.
Walczak MS, Lawniczak-Jablonska K, Wolska A, Sienkiewicz A, Suárez L, Kosar AJ, Bohle DS.
Understanding chloroquine action at the molecular level in antimalarial therapy: X-ray absorption studies in dimethyl sulfoxide solution. J Phys Chem B. 2011 Feb 10;115(5):1145-50. Epub 2010 Dec 29.