Youla Tsantrizos

Professor

Education

B.Sc. (McGill University, 1977)
M.Sc. (McGill University, 1979)
Ph.D. (McGill University, 1990)
Postdoctoral Fellow (Brown University, 1991)

Positions Held

Group Leader/Distinquished Scientist (Boehringer Ingelheim, 2003-2008)
Senior Research Scientist (Boehringer Ingelheim, 1998-2003)
Visiting Professor (Stanford University, 1997)
Assistant & Associate Professor (Concordia University, 1991-97)
Professor Vanier College (1979 - 1987)

Awards & Recognitions

Boehringer Ingelheim Scientific Advancement Grant in Catalysis (2017)
Merck, Sharpe & Dohme Grant for Translational Research (2017-2019)
Boehringer Ingelheim Scientific Advancement Award in Synthesis and Medicinal Chemistry (2016)
Scientific Advisory Board Member, Clearsynth (2015 – present)
Past President of the Canadian Society for Chemistry (2015 – 2016)
President of the Canadian Society for Chemistry (2014 – 2015)
Vice President of the Canadian Society for Chemistry (2013 – 2014)
Associate Editor, Frontiers in Chemical Biology (2013-present)
Queen Elizabeth II Diamond Jubilee Medal 2012
Fessenden Professorships in Science Innovation, 2011
International Boehringer Ingelheim Research & Development Award, 2000
Convocation Commencement Speaker, Vanier College (1992)
Dean's Honour List, McGill University 1990
Canadian Pacific Fellowship in Biotechnology, 1988-1990
Equipes et Seminnaires (Collegial) FCAR, 1986 - 1988


International Committee Member, Faculty Hiring and Promotions, Universities of Greece
Committee Member, NSERC Discovery Grants
Committee Member, CIHR Foundation Grants
Committee Member, CIHR Prof-of-Principal Grants
Committee Member, Ontario Institute for Cancer Research, Review of Investigator Award Retention and Promotion
Member, NSERC CREATE Bionanomachines
Member, CIHR Drug Design Training Program (DDTP)

Office: 316
Phone: (514)398-3638
Email: Youla.Tsantrizos [at] mcgill.ca
Web Page: http://tsantrizos-group.mcgill.ca

Member of the protein structural research center GRASP http://grasp.mcgill.ca
Mentor in the McGill Canadian Institute of Health Research Training Program in Drug Development (http://www.medicine.mcgill.ca/trainingindrugdev/)

Lab: Otto Maass 300
Lab Phone: 514-398-5675

Research Themes:

Chemical Biology 

Synthesis/ Catalysis

Research Description:

Phosphorus-containing compounds constitute an important class of human therapeutics. Additionally, such compounds are valuable molecular tools in chemical biology and important ligands in enantioselective organic synthesis. The main focus of our research is the design and synthesis of phosphorus-containing heterocyclic compounds, including compounds with a chiral phosphorus center. We are developing synthetic methodologies that (a) are amenable to high throughput parallel synthesis of compound libraries and (b) result in high enantiomeric purity on the phosphorus atom.  Subsequently, we use or biologically active ligands to interrogate various biochemical pathways involved in cancer and neurodegeneration. Furthermore, we used our P-chiral phosphorus ligands to explore novel transition metal-catalyzed reactions and non-metal mediated organocatalytic reactions that are important in the multi-kilo production scale of human pharmaceuticals. 


Currently Teaching:

CHEM 211 Organic Chemistry 1 Lectures 3 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 212 Intro Organic Chemistry 1 4 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 224 Organic Chemistry Laboratory 1 1 Credits
    Offered in the:
  • Fall
  • Winter
  • Summer

CHEM 382 Course not available