Discovery points to possible target for cancer drugs

McGill University researchers have discovered a mechanism through which mitochondria, the energy factory of our body’s cells, play a role in preventing cells from dying when the cells are deprived of nutrients – a finding that points to a potential target for next-generation cancer drugs.

The research, published in Molecular Cell, builds on previous work by McGill professor Nahum Sonenberg, one of the senior authors of the new study.

Classified as: Heidi McBride, mitochondria
Published on: 22 Sep 2017

A team of scientists led by Dr. Michel Desjardins from the University of Montreal and Dr. Heidi McBride from the Montreal Neurological Institute and Hospital (MNI) at McGill University have discovered that two genes associated with Parkinson's disease (PD) are key regulators of the immune system, providing direct evidence linking Parkinson's to autoimmune disease.

Using both cellular and mouse models, the team has shown that proteins produced by the two genes, known as PINK1 and Parkin, are required to prevent cells from being detected and attacked by the immune system.

Classified as: genetics, mitochondria, Parkinson's, Parkinson's disease, autoimmune disease, PINK1, Parkin
Published on: 27 Jun 2016

The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. But a new study by scientists at McGill University finds that ubiquinone is not a crucial antioxidant -- and that consuming it is unlikely to provide any benefit.

Classified as: Biology, Research, mitochondria, food, aging, nutrition, McGill News, antioxidant, Coenzyme Q10, dietary supplement, Hekimi, Nature Communications, ubiquinone, free radicals
Published on: 6 Mar 2015

Research opens door to new drug therapies for Parkinson’s disease

Classified as: brain, genetic, mitochondria, Parkinson's, neurological disease, McGill, drugs, Ted Fon, Montreal Neurological Institute and Hospital, Kalle Gehring, protein
Published on: 9 May 2013

International study with researchers at The Neuro reveals links with other neurodegenerative diseases

MONTREAL, October 9, 2012  - Scientists at the Montreal Neurological Institute and Hospital – The Neuro,  McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders. 

Classified as: adult, Alzheimer's, chiild, Gene, genetic, infant, mitochondria, mutation, neurological, Parkinson's, rare disorders
Published on: 9 Oct 2012