New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma. A McGill-led study published in Nature Communications reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy.

This approach, led by the laboratory of Arezu Jahani-Asl, Assistant Professor of Medicine at McGill University, was successful in preclinical mouse models where the deletion of the OSMR gene resulted in a significant improvement of tumour response to therapy and expanded lifespan.

Classified as: brain, Cancer, OSMR, Gene, glioblastoma, gene targeting, Arezu Jahani-Asl
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Published on: 17 Aug 2020

Journal de Metro Feature:

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Classified as: Gene, disease, Montreal, cftr, cftrc
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Published on: 23 Jan 2017

Montreal Gazette Feature:

Read the entire article HERE.

Classified as: Gene, cftr, cftrc, hts, renaud
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Published on: 23 Jan 2017
Microglies

Un événement commun se produit dans maintes pathologies du système nerveux : des cellules microgliales, qui sont des sentinelles chargées de surveiller, se muent en combattantes.  Cellules immunitaires du système nerveux, les microglies ingèrent et détruisent des agents pathogènes et des cellules nerveuses lésées. Bien que ce processus soit crucial dans l’organisme, on savait jusqu’à présent très peu au sujet des mécanismes moléculaires d’activation des microglies.

Classified as: Gene, développement, immunitaires, le cerveau, les cellules microgliales, troubles neurologiques
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Published on: 15 Oct 2012
Microglia

In many pathologies of the nervous system, there is a common event - cells called microglia are activated from surveillant watchmen into fighters.  Microglia are the immune cells of the nervous system, ingesting and destroying pathogens and damaged nerve cells. Until now little was known about the molecular mechanisms of microglia activation despite this being a critical process in the body.

Classified as: brain, Development, Gene, neurological, immune response, microglia, epilepsy, injury, neurological disease, pathology, trauma
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Published on: 15 Oct 2012

International study with researchers at The Neuro reveals links with other neurodegenerative diseases

MONTREAL, October 9, 2012  - Scientists at the Montreal Neurological Institute and Hospital – The Neuro,  McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders. 

Classified as: adult, Alzheimer's, chiild, Gene, genetic, infant, mitochondria, mutation, neurological, Parkinson's, rare disorders
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Published on: 9 Oct 2012
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