Event

CCVC Seminar: Dr. Marisa Kozlowski - Oxygen Driven Fragment Coupling by Activation of C-H, N-H, and O-H Bonds

Tuesday, March 8, 2016 13:00to14:30
Maass Chemistry Building Rm 10, 801 rue Sherbrooke Ouest, Montreal, QC, H3A 0B8, CA

Inspired by Nature's use of oxidative couplings to construct carbon-carbon, carbon-oxygen, and carbon-nitrogen bonds in many natural products, we have undertaken studies of these important transformations. The development of selective catalytic processes for naphthol coupling, phenol coupling, N-arylation, and alkyl C–H acivation that utilize oxygen as the terminal oxidant will be discussed.  Applications to the synthesis of chiral natural products including nigerone, hypocrellin, cercosporin, and bisoranjidiol as well as to the synthesis of novel optically active materials will be presented.  

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