Methotrexate-resistant human dihydrofolate reductase: Directed evolution of a selectable marker for mammalian cells
Joëlle Pelletier, Départements de chimie et biochimie, Université de Montréal. Host: Isabelle Rouiller.
Role and regulation of the GATA4 transcription factor in gonadal function: More than just a matter of the heart
Robert Viger, Centre Hospitalier de l'Université Laval (CHUL) Research Centre, Université Laval. Host: Carlos Morales.
Mechanisms of initiation and control of skeletal mineralization – Implications for the treatment of vascular calcification
Jose-Luis Millan, Burnham Institute for Medical Research, La Jolla Cancer Research Center, San Diego. Host: Marc McKee.
The role of protein-protein interactions in the biosynthesis and secretion of the E. coli siderophore enterobactin
Peter Pawelek, Concordia University. Host: Isabelle Rouiller.
Lecture/slide show by Dr. Ehab Abouheif, Biology, McGill. Ants are remarkable in that depending only on environmental cues, such as food and temperature, an ant queen will lay an egg that develops into a winged queen or a wingless worker. Only a small number of genes control the embryonic development of very diverse animal types. Dr. Abouheif studies evolutionary processes in ants and fish. How these genes evolve and react to the environment is contributing to cancer research.
Lecture/slide show by Dr. Lyle Whyte, Natural Resource Sciences, Macdonald Campus, McGill. Researchers have discovered that microbes make up most of the Earth's biomass, and they are found in virtually every environment on Earth. Dr. Whyte is discovering micro-organisms in the Canadian Arctic that have existed for millions of years. His presentation will show how the extraordinary metabolic capacity of microbes can be harnessed for many environmental, energy and industrial applications.
Distance learning in Occupational Health Sciences at McGill: What, why, how? Could it be used to teach Epidemiology and Biostatistics students?
Dr. Gilles Thériault, professor, Dept of Epidemiology, Biostatistics and Occupational Health, McGill
James A. Hanley, Epidemiology and Biostatistics, McGill The calculation of probabilities is central to statistical inferences; however, researchers, especially those who are not trained in probability, often have difficulty (or err) when setting up correct probability calculations. Probabilities of seemingly rare events that are assessed after the fact are especially problematic. In an early report, I described three examples where probability specialists themselves have been "near-sighted" in assessing or predicting usual and unusual events generated by state lotteries. In one example, a lottery official offered "data" which one should expect from a fair lottery; unfortunately, the logic used to "predict the usual" was faulty. In the two others, the unusual (what one should not often expect) was calculated to be much more unusual than it really was. Since then, the story of a fourth -- and seemingly very unusual -- lottery event, and the official statistical reaction to it, were carried in worldwide public
Is depression an independent predictor of post-acute myocardial infarction outcomes? A structural equation modeling approach
Dr. Brett Thombs, assistant professor, Dept of Psychiatry, McGill, and research associate, Dept of Psychiatry, Sir Mortimer B. Davis – Jewish General Hospital
Dr. Jay Kaufman, associate professor, Dept of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill.