Chemical Society Seminar: Dr. Nicole F. Steinmetz - From black-eyed peas to nanotechnology: engineering plant virus-based therapeutics
Nanoscale engineering is revolutionizing the way we prevent, detect and treat diseases.
Chemical Society Seminar: Dr. Julie Biteen - Single-Molecule Imaging and Plasmon-Enhanced Fluorescence: Understanding Bacterial Function on the Nanoscale
By beating the diffraction limit that restricts traditional light microscopy, single-molecule fluorescence imaging is a precise, noninvasive way to sensitively probe position and dynamics.
Class of Alain Desgagné
Class of Felicia Moye
The Tsantrizos and Berghuis groups unravel important mechanistic insight into metabolic regulation/dysregulation with important implications for the treatment of cancer
Human farnesyl pyrophosphate synthase (hFPPS) plays a key role in the prenylation of small GTPases, such as RAS and RAP 1A, which are intimately involved in oncogenesis. An allosteric pocket of the enzyme has been of particular interest as a therapeutic target, however, its natural biological function has been (until now) unknown. The teams of Berghuis (Biochemistry) and Tsantrizos (Chemistry) have just reported that the catalytic product of hFPPS, farnesyl pyrophosphate (FPP), bind to this pocket and locks the enzyme in a conformationally inactive state.
Class of Aiyun Huang and Fabrice Marandola
Class of Michael McMahon
Class of Annamaria Popescu
Class of Kyoko Hashimoto
Class of Timothy Hutchins