A new study shows that memory pathology in older mice with Alzheimer’s disease can be reversed with treatment. The study by researchers from the Montreal Neurological Institute and Hospital - The Neuro, at McGill University and at Université de Montréal found that blocking the activity of a specific receptor in the brain of mice with advanced Alzheimer’s disease (AD) recovers memory and cerebrovascular function.
What is ALS?
Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig’s disease, is a neurodegenerative disease in which progressive muscle weakness leads to paralysis. ALS is a result of the death of motor neurons (nerve cells) in the brain and spinal cord that control voluntary muscle movement. Most people survive less than five years following diagnosis, but a small percentage of patients live for ten years or even longer. So far, there is no cure.
Dr. Robert J.
Research opens door to new drug therapies for Parkinson’s disease
McGill University researchers have unlocked a new door to developing drugs to slow the progression of Parkinson’s disease. Collaborating teams led by Dr. Edward A. Fon at the Montreal Neurological Institute and Hospital -The Neuro, and Dr. Kalle Gehring in the Department of Biochemistry at the Faculty of Medicine, have discovered the three-dimensional structure of the protein Parkin.
January 29, 2013 - Addiction to cigarettes, drugs and other stimulants has been linked in the past to the brain’s frontal lobes, but now there is scientific evidence that indicates where in the frontal cortex addiction takes hold and how. Addiction could be a result of abnormal communication between two areas of the frontal lobes linked to decision-making. The discovery will undoubtedly stimulate clinical work on new therapies for millions of people who suffer from addiction.
The research by lead authors Dr.
January 28, 2013 - A revolutionary technology has the ability to detect and diagnose Alzheimer’s disease with unprecedented accuracy. The computerized technique known as SNIPE analyzes magnetic resonance imaging (MRI) scans to capture patterns of atrophy specific to the disease in brain structures, specifically the hippocampus and entorhinal cortex. Diagnosing Alzheimer’s disease (AD) is still an inexact science, relying mainly on the patient's symptoms and performance on memory tests.
November 8 2012 - After a worldwide search, the renowned Montreal Neurological Institute and Hospital – The Neuro – of McGill University and the McGill University Health Centre has a new director, Guy Rouleau, MD, PhD, FRCPC, OQ. Dr. Rouleau, a prominent Quebec clinician-scientist recognized for his contributions to science and society, will also hold the Wilder Penfield Chair in Neuroscience as Professor of Neurology and Neurosurgery at McGill.
In many pathologies of the nervous system, there is a common event - cells called microglia are activated from surveillant watchmen into fighters. Microglia are the immune cells of the nervous system, ingesting and destroying pathogens and damaged nerve cells. Until now little was known about the molecular mechanisms of microglia activation despite this being a critical process in the body.