Normal and abnormal neural control of cardiac activity

The cardiac autonomous nervous system (CAS) constantly modulates electrical dynamics of the heart, and its dysfunction often leads to cardiac arrhythmia. Members of our groups (Glass, Vigmond, Vinet) are involved in a cell to bedside investigation of the CAS. It involves the recording of long lasting ECGs in patients, of multichannel electrograms as well as neural signals in the different location of the CAS in animal preparation. The analysis of these data is complemented by modelling work spanning from the isolated cardiac myocyte to complete heart-torso, including the hierarchical organisation of the CAS. The problems encountered are within the expertise of many other members of the CAMBAM (e.g. statistical multiple time series analysis, modelling of control systems, cell behaviour and neural system) and this will catalyze fruitful collaborations.