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Lady Davis Institute – Bloomfield Centre for Research in Aging

The Bloomfield Centre for Research in Aging (BCRA) was established in 1989 to promote research into all aspects of aging, concentrating on cellular and molecular mechanisms of healthy aging and age-related diseases.  The Centre occupies the fourth floor of the Lady Davis Institute for Medical Research at the Jewish General Hospital, a McGill teaching hospital.

Research activities are focused in six areas:

  • Basic cellular mechanisms of aging
  • Basic mechanisms of neurodegenerative disease
  • Clinical research into aging and dementia
  • Population studies of aging and dementia
  • Health services delivery to the elderly
  • Aging Bone, bone cell differentiation, Apoptosis and Aging

 

Here is a list of faculty members currently conducting research.  Follow the links to read about each investigator's research interests, publications and the work being done in their laboratory.

HOWARD CHERTKOW, DIRECTOR

Tel: (514) 340-8260 loc. 5129
E-mail: howard [dot] chertkow [at] mcgill [dot] ca

Research:  Alzheimer's Disease and dementia.

Dr. Chertkow's field of research is cognitive neuroscience - it attempts to understand the brain basis of behaviour using studies of normal subjects, brain imaging, and testing of individuals with brain damage. His initial focus was cognitive neuropsychological investigations of one component of long-term memory, namely semantic memory.

More info:  http://www.bloomfieldcentre.org/e/bios/h_chertkow.htm

CHANTAL AUTEXIER,  PROFESSOR

Departments of Anatomy and Cell Biology, and Medicine, McGill University

Tel: (514) 340-8260 loc. 4651
E-mail: chantal [dot] autexier [at] mcgill [dot] ca

Research:  Understanding the mechanism of action of telomerase and its regulation, in mammalian organisms.  

Life expectancy in industrialized countries has nearly doubled during the 20 th century. Longer life expectancy leads to the increased risk of exposure to age-related disorders, including neurodegeneration and cancer, and the associated healthcare related costs. Molecular mechanisms mediating the cellular changes that occur during ageing, and age-related diseases include oxidative stress, DNA damage, genomic instability, telomere reduction, and cell death.

More info: http://www.bloomfieldcentre.org/e/bios/c_autexier.htm

HOWARD BERGMAN

Division of Geriatric Medicine (Department of Medicine), McGill University

Tel: (514) 340-7501
E-mail: howard [dot] bergman [at] mcgill [dot] ca

Research: Dr. Bergman, currently head of the Division of Geriatric Medicine at McGill, is a leader in the field of developing health services delivery for the elderly.

Howard Bergman MD is the first Dr. Joseph Kaufmann Professor of Geriatric Medicine and is currently Head of the Division of Geriatric Medicine at McGill University, as well as at the Jewish General Hospital. He is also an investigator at the Centre for Clinical Epidemiology and Community Studies.

More info: http://www.bloomfieldcentre.org/e/bios/h_bergman.htm

ANDREA LEBLANC

Department of Neurology and Neurosurgery, McGill University

Tel: (514) 340-8222 loc. 4837 / (514) 340-8222 loc. 4976
E-mail: andrea [dot] leblanc [at] mcgill [dot] ca

Research:  Pathophysiology of neurodegenerative diseases in aging individuals.

The long-term objective of Dr. LeBlanc’s research is to investigate the mechanisms responsible for the pathophysiology of neurodegenerative diseases in aging individuals. Her main research goal is to test the hypothesis that unscheduled death of neurons may be the leading physiological abnormality contributing to the loss of critical a mass of functional neurons in the central nervous system (CNS), and that this loss is the underlying cellular reason for the CNS deficit in Alzheimer's Disease (AD) and other neurodegenerative diseases. Her laboratory investigates various cell death pathways in human primary neuron cultures and their role in AD and prion disease pathology.

More info:  http://www.bloomfieldcentre.org/e/bios/a_leblanc.htm

HEMANT PAUDEL

Department of Neurology and Neurosurgery, McGill University

Tel: (514) 340-8260 loc. 4866
E-mail: hpaude [at] po-box [dot] mcgill [dot] ca

Research: Elucidate the molecular mechanism of tau phosphorylation in normal brain and to determine how this regulation fails in Alzheimer's disease brain.

Senile plaques and neurofibrillary tangles (NTs) are the two neuropathological hallmarks of AD. The extended topographical distribution of NTs provides a reliable pathological correlation to the degree of dementia, the central symptom of AD. Ultrastructurally, NTs contain paired helical filaments (PHFs). PHFs are composed of abnormally hyperphosphorylated microtubule-associated tau protein. Carrying more phosphate than it should makes tau unable to perform its normal function leading to loss of tau function, cytoskeletal disruption, PHF formation, and neurodegeneration.

More info: http://www.bloomfieldcentre.org/e/bios/h_paudel.htm

STÉPHANE RICHARD

Departments of Medicine and Oncology, McGill University

Tel: (514) 340-8260 loc. 4470
E-mail: stephane [dot] richard [at] mcgill [dot] ca

Lab:  http://www.ladydavis.ca/en/richardlab

Research:  The roles of protein arginine methylation and RNA binding proteins in diseases such as cancer and multiple sclerosis.

Stéphane Richard is a scientific expert in molecular biology research in the fields of cancer and neuroscience. His research is aimed at understanding the roles of protein arginine methylation and RNA binding proteins in diseases such as cancer and multiple sclerosis. Dr. Richard's group is actively pursing the molecular roles of protein methylation and RNA binding proteins in epigenetics, RNA metabolism, and DNA damage signaling.

More info: http://www.bloomfieldcentre.org/e/bios/s_richard.htm

URI SARAGOVI

Department of Pharmacology and Therapeutics

Tel: (514) 340-8222 loc. 5055
E-mail: uri [dot] saragovi [at] mcgill [dot] ca

Research:  Receptor Structure- Function Relationships and Signal Transduction Event        

More info:  http://www.medicine.mcgill.ca/pharma/displaypharma.asp?Pharma_ID=44

HYMAN SCHIPPER

Departments of Neurology & Neurosurgery and Medicine (Geriatrics), McGill University

Tel: (514) 340-8260 loc. 5588
E-mail: hyman [dot] schipper [at] mcgill [dot] ca

Research:  Neuroendocrinology, Brain Aging, Oxidative Stress and Neurodegenerative Disease.

Since 1976, Dr. Schipper’s research efforts have been largely concentrated at the intersections of Neuroendocrinology, Brain Aging, and Neurodegenerative Disease. Three papers (1980-3) provided the earliest published evidence that chronic exposure to ovarian estradiol promotes aging-related degenerative (neuritic and glial) changes in the rodent hypothalamus implicated in reproductive senescence and the development of polycystic ovaries.

More info: http://www.bloomfieldcentre.org/e/bios/h_schipper.htm