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Bioengineering Courses (2014-15)

The following courses are being offered as complementary courses (or technical complementaries, for Engineering) to students in the specified programs below. For scheduling information, visit the Minerva Class Schedule.

TO REGISTER: Please submit a Course_Authorization_Form signed by your Departmental Advisor to the Macdonald Engineering Building, Room 270.

BIEN 310 Introduction to Biomolecular Engineering (3 credits)
Forward and reverse engineering of biomolecular systems. Principles of biomolecular thermodynamics and kinetics. Structure and function of the main classes of biomolecules including proteins, nucleic acids, and lipids. Biomolecular systems as mechanical, chemical, and electrical systems. Rational design and evolutionary methods for engineering functional proteins, nucleic acids, and gene circuits.  Rational design topics include molecular modeling, positive and negative design paradigms, simulation and optimization of equilibrium and kinetic properties, design of catalysts, sensors, motors, and circuits. Evolutionary design topics include evolutionary mechanisms, fitness landscapes, directed evolution of proteins, metabolic pathways, and gene circuits. Systems biology and synthetic biology.
Instructor Prof. Yu (Brandon) Xia
*Open to students in Mechanical Engineering, Mining and Materials Engineering, Bioresource Engineering, Human Genetics, Physiology and Quantitative Biology.

BIEN 320: Molecular, Cellular and Tissue Biomechanics (3 credits)
This course considers the basic mechanics of biological building blocks, focusing on the cytoskeleton, with examples from pathology. At the macromolecular level: weak/variable crosslinking & hydrolysis driven athermal processes. At the cellular/tissue level: cell architecture and function. Modern analytical techniques capable of single-molecule to tissue scale measurements are discussed.
Instructor: Prof. Allen Ehrlicher
*Open to students in Mechanical Engineering, Chemical Engineering, Mining and Materials Engineering, Bioresource Engineering, Human Genetics, Physiology and Quantitative Biology.

BIEN 510: Nanoparticles in the Medical Sciences (3 credits)
Introduction to the interdisciplinary field of biomedical uses of nanotechnology. Emphasis on emerging nanotechnologies and biomedical applications including nanomaterials, nanoengineering, nanotechnology-based drug delivery systems, nano-based imaging and diagnostic systems, nanotoxicology, and translating nanomedicine into clinical investigation.
Instructor: Prof. J. Matt Kinsella
*Open to students in Mechanical Engineering, Chemical Engineering, Mining and Materials Engineering, Biomedical Engineering, Bioresource Engineering, Human Genetics, Physiology and Quantitative Biology.

BIEN 520: High Throughput Bioanalytical Devices (3 credits)
Introduction to the field of high throughput screening (HTS) analytical techniques and devices used for genomics, proteomics and other “omics” approaches, as well as for diagnostics, or for more special cases, e.g., screening for biomaterials. Introduction into the motivation of HTS and its fundamental physico-chemical challenges; techniques used to design, fabricate and operate HTS devices, such as microarrays and new generation DNA screening based on nanotechnology. Specific applications: DNA, protein and diagnostic and cell and tissue arrays.
Instructor: Prof. Dan Nicolau
*Open to students in Mechanical Engineering, Chemical Engineering, Mining and Materials Engineering, Biomedical Engineering, Bioresource Engineering, Human Genetics, Physiology and Quantitative Biology.

BIEN 530: Imaging and Bioanalytical Instrumentation (3 credits)
Microscopy techniques with application to biology and medicine. Practical introduction to optics and microscopy from the standpoint of biomedical research. Discussion of recent literature; hands-on experience. Topics include: optics, contrast techniques, advanced microscopy, and image analysis.
Instructor: Prof. Adam Hendricks
*Open to students in Mechanical Engineering, Mining and Materials Engineering, Biomedical Engineering, Bioresource Engineering, Human Genetics, Physiology and Quantitative Biology.