Yu (Brandon) Xia

Associate Professor

Canada Research Chair in Computational and Systems Biology

Ph.D. Stanford University
B.S. Peking University

Macdonald Engineering Building, Room 389
brandon.xia [at] mcgill.ca (e-mail)

Research Interests

  • Construction of genome-scale computer models of biomolecular networks with high spatial and temporal resolutions.
  • Use of genome-scale models to probe the biophysical and engineering principles of biological networks.
  • Use of genome-scale models to study the systems biology of diseases
  • Computational Structural Biology. Prediction and analysis of protein structure and function; evolutionary and design principles of proteins
  • Computational Systems Biology. Prediction and analysis of protein networks; evolutionary and design principles of protein networks.
  • Bioinformatics. Development and application of bioinformatics algorithms to analyze biological sequence, structural and functional data.


  • BIEN 310 Introduction to Biomolecular Engineering (3 credits)
  • BIEN 410 Computational Methods in Biomolecular Engineering (3 Credits)

Selected Publications

Structural principles within the human-virus protein-protein interaction network.
Franzosa EA, Xia Y. 
Proc. Natl. Acad. Sci. USA 108: 10538-10543 (2011).

Structural determinants of protein evolution are context-sensitive at the residue level.
Franzosa EA, Xia Y. 
Mol. Biol. Evol. 26: 2387-2395 (2009).

Relating three-dimensional structures to protein networks provides evolutionary insights. 
Kim PM, Lu LJ, Xia Y, Gerstein MB. 
Science 314: 1938-1941 (2006).

Visit MEDLINE indexed publications and the following list for more.